Visual Findings of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Patients with Cardiac Sarcoidosis
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概要
- 論文の詳細を見る
Objective The purpose of this study was to evaluate the cardiac sarcoidosis (CS) activity according to the classified visual uptake pattern using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) and assess the uptake pattern based on the free fatty acid (FFA) levels. Methods Nineteen CS subjects who underwent 18F-FDG PET/CT examinations with heparin loading (HL) were recruited to evaluate their CS activity. The 18F-FDG uptake in the heart was classified into five categories ("none," "diffuse" and "diffuse at base," regarded as stable CS, and "focal" and "focal on diffuse," regarded as de novo or worsening CS). The subject data were compared with the 18F-FDG PET/CT findings in 13 healthy volunteers. The FFA serum levels were assessed in 10 patients with CS and all volunteers. Results The sensitivity and specificity of 18F-FDG PET/CT with HL were 75% (6/8) and 73% (8/11), respectively. The major pattern of cardiac 18F-FDG uptake was "diffuse at base." Ten of the 32 subjects, including the control group, exhibited this pattern. The FFA serum levels before heparin administration were statistically significantly different between the patients with the "none" pattern and those with the "diffuse" and "diffuse at base" patterns. There were no significant correlations between the FFA serum levels after heparin administration and the 18F-FDG uptake patterns. Conclusion "Diffuse at base" is the major 18F-FDG uptake pattern associated with inadequate physiologic 18F-FDG suppression. This pattern should be carefully interpreted when examining the 18F-FDG PET/CT images of CS patients. Additionally, increased FFAs levels associated with HL may not completely suppress the physiologic myocardial FDG uptake.
- 一般社団法人 日本内科学会の論文
著者
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Hiroe Michiaki
Department Of Cardiology International Medical Center Of Japan
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Ito Kimiteru
Department Of Nuclear Medicine International Medical Center Of Japan
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Okazaki Osamu
Department Of Cardiology International Medical Center Of Japan
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Kubota Kazuo
Department Of Medicine And Division Of Rehabilitation Kusatsu Branch Hospital Gunma University Schoo
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Morooka Miyako
Department of Nuclear Medicine, National Center for Global Health and Medicine, Japan
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Hiroe Michiaki
Department of Cardiology, National Center for Global Health and Medicine, Japan
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Minamimoto Ryogo
Department of Nuclear Medicine, National Center for Global Health and Medicine, Japan
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