DETERMINATION OF REGIONAL MYOCARDIAL BLOOD FLOW WITH ^<13>N-AMMONIA POSITRON EMISSION TOMOGRAPHY DURING LOW-GRADE EXERCISE FOR EVALUATING CORONARY ARTERY STENOSIS
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概要
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We measured regional myocardial blood flow (RMBF) by positron emission tomography (PET) with ^<13>N-ammonia at rest and during low-grade exercise using a bicycle ergometer fixed at 25 watts for 6.5 min. The ischemic area with severe coronary artery stenosis was evaluated in terms of quantitative RMBF. The study was performed in 46 subjects consisting of 19 patients with old myocardial infarction, 20 with effort angina pectoris, and 7 normal individuals. RMBF was calculated using the radioactivity in myocardial tissue measured by PET and the radioactivity in arterial blood. The PET data were compared with coronary arteriographic findings and ECG findings. When the analysis was restricted to the anterior wall of the myocardium, it was found that exercise caused RMBF to increase by 44.9% (n=28) in normal area, to increase by 23.3% (n=37) in severely stenotic area (stenosis≧90%), and to decrease by 17.4% (n = 20) in infarcted area. When we considered only the infarcted area of the entire heart, exercise caused RMBF to decrease by 26.6% (n=30) in the area of angiographically positive collaterals, and to increase by 0.8% (n=31) in the area of negative collaterals. Thus, we were able to quantitate the degree of ischemia in myocardium that was associated with severe coronary artery stenosis. By application of low-grade exercise, RMBF in normal myocardium increased, while RMBF in myocardium perfused by collaterals decreased.
- 社団法人日本循環器学会の論文
- 1994-04-20
著者
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Katagiri T
Department Of Medicine Division Of Cardiology Shown University School Of Medicine
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Katagiri Takashi
Third Dept. of Internal Medicine, Showa University
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Akutsu Yasushi
Division of Cardiology, Department of Medicine, Showa University School of Medicine
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Yamanaka Hideyuki
Yamanaka Naika Clinic
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Akutsu Yasushi
Third Department of Internal Medicine, Showa University School of Medicine
-
Yamanaka Hideyuki
Third Department of Internal Medicine Showa University School of Medicine
-
Harumi Kenichi
Department of Cardiology, Shouwa University Fujigaoka Hospital
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KASHIDA Mitsuo
Division of Cardiology, International Medical Center of Japan
-
Okazaki Osamu
Department of Cardiology, International Medical Center of Japan
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HARA TOSHIHIKO
Department of Biology, Faculty of Science, Tokyo Metropolitan University
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Kashida Mitsuo
Division Of Cardiology International Medical Center Of Japan
-
Hara Toshihiko
Department Of Cardiology And Department Of Radiology National Nakano Chest Hospital
-
Watanabe Takuya
Third Department of Internal Medicine
-
Hasegawa Mitsugu
Third Department of Internal Medicine, Showa University School of Medicine
-
Harumi Kenichi
Showa Univ Fujigaoka Hosp
-
Akutsu Yasushi
Department Of Medicine Division Of Cardiology Showa University School Of Medicine
-
Michihata Tetsurou
Division of Cardiology, International Medical Center of Japan
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MICHIHATA TETSUROU
Department of Cardiology and Department of Radiology, National Nakano Chest Hospital
-
AKUTSU YASUSHI
Ogikubo Ceneral Hospital
-
Katagiri Takashi
Third Department Of Internal Medicine Showa University School Of Medicine
-
Michihata Tetsurou
Division Of Cardiology International Medical Center Of Japan
-
Kashida Mitsuo
Department Of Cardiology International Medical Center Of Japan
-
Harumi Kenichi
Department Of Cardiology Shouwa University Fujigaoka Hospital
-
Harumi Kenichi
Division Of Cardiology Nakano National Chest Hosp.
-
Okazaki Osamu
Department Of Cardiology International Medical Center Of Japan
-
Yamanaka Hideyuki
Third Department Of Internal Medicine
-
Hasegawa Mitsugu
Third Department Of Internal Medicine Showa University School Of Medicine
-
Okazaki Osamu
Division Of Cardiology Nakano National Chest Hosp.
-
Hara Toshihiko
Department Of Biology Faculty Of Science Tokyo Metropolitan University
-
Kusuyama Taro
Department Of Medicine Division Of Cardiology Showa University School Of Medicine
-
Katagiri Takashi
Third Department Inter Nat Medicine Showa University
-
Watanabe Takuya
Third Department Of Internal Medicine Showa University School Of Medicine
-
Akutsu Yasushi
Third Department of Internal Medicine (Division of Cardiology), Showa University School of Medicine
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