Effect of combination therapy with alogliptin and lansoprazole on glycemic control in patients with type 2 diabetes
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概要
- 論文の詳細を見る
The main purpose of the current study was to investigate the effect of a combination of alogliptin [a dipeptydil peptidase (DPP)-4 inhibitor] and lansoprazole [a proton pump inhibitor (PPI)] compared with alogliptin mono-therapy on glycemic control in patients with type 2 diabetes. This study was a multicenter randomized open-label study. One hundred type 2 diabetic patients were randomly assigned to either the alogliptin with lansoprazole group or the alogliptin mono-therapy group. After 3 months of treatment, the changes in hemoglobin (Hb)A1c, fasting plasma glucose (FPG), serum gastrin, homeostasis model assessment (HOMA)-β, and HOMA-insulin resistance (IR) were evaluated. A significant decrease in HbA1c and FPG, and a significant increase in HOMA-β were observed in both groups (all with P <0.0001). However, there were no significant differences in changes in HbA1c, FPG, or HOMA-β before and after therapy between the combination and alogliptin mono-therapy group (P =0.2945, P =0.1901, P =0.3042, respectively). There was a significant elevation of serum gastrin in the combination group compared with the alogliptin mono-therapy group (P =0.0004). This study showed that, although combination therapy with alogliptin and lansoprazole more effectively elevated serum gastrin levels compared with alogliptin mono-therapy, the effect of the combination therapy on glycemic control was equal to that of alogliptin mono-therapy during a 3-month study period.
- 一般社団法人 日本内分泌学会の論文
著者
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Inukai Toshihiko
Department Of Internal Medicine Dokkyo Medical University Koshigaya Hospital
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Suzuki Tatsuhiko
Department Of Electrical Engineering Faculty Of Engineering Science University Of Tokyo
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Hara Kenji
Department Of Biology Faculty Of Education Tokyo Gakugei University
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Terasawa Tomoko
Department Of Clothing Science Jissen Women's Oniversity
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Takebayashi Kohzo
Department Of Internal Medicine Dokkyo Medical University Koshigaya Hospital
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Naruse Rika
Department Of Internal Medicine Dokkyo Medical University Koshigaya Hospital
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Suetsugu Mariko
Department of Internal Medicine, Dokkyo Medical University Koshigaya Hospital
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Sakurai Shintaro
Department of Electrical and Electronic Engineering, Akita University
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Tsuchiya Takafumi
Department of Internal Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Japan
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Inukai Toshihiko
Department of Internal Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Japan
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Hori Kenichiro
Department of Internal Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Japan
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Aoki Hiromi
Higashiwashinomiya Hospital, Kuki, Japan
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Hamasaki Takashi
Hamasaki Clinic, Kasukabe, Japan
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Shuutou Hiroshi
Iryouhoujinkenshinkai-minamikoshigayakenshinkai Clinic, Koshigaya, Japan
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