嗅上皮における神経栄養因子受容体の分布:嗅球除去に伴うNGF受容体の発現

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Topographical expression of nerve trophic factor receptors in the murine olfactory epithelium after bulbectomy was studied immunohistochemically using high-affinity binding of the trk group of tryosine protein kinases. We used three polyclonal antibodies against trk, trkB and trkC, which specifically recognize nerve growth factor (NGF) receptor, brain-derived neurotrophic factor (BDNF) receptor and neurotrophin-3 (NT-3) receptor, respectively. Among the three antibodies used, trk immunoreactivity was most prominent after bulbectomy. In this experiment, the possible regenerative or degenerative effects of bulbectomy were detected over the course of 28 days following surgery in adult mice whose olfactory bulbs had been removed. In these mice, trk immunoreactivity in regenerating cells and nervi of the olfactory epithelium was increased 7-28 days after bulbectomy, while trkB and trkC immunoreactivities in olfactory nervi were increased 1-21 days after bulbectomy. Taken together, these results suggest that a high-affinity NGF-receptor is produced in the olfactory cells and distributed to the regenerating olfactory system. Among the three neurotrophic factors, i. e. NGF, BDNF and NT-3, NGF may play the most important role in the olfactory pathway.
耳鼻咽喉科臨床学会の論文