Distribution to Tonsil and Maxillary Sinus Mucosa and Clinical Evaluation of Ofloxacin.

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The distribution of ofloxacin (OFLX) in the palatal tonsil and maxillary sinus mucosa was quantitatively analyzed. OFLX (100mg), lomefloxacin (100mg), and tosufloxacin (75mg) were administered orally 2 hours before surgery. The tissue concentration of OFLX was 1.61±0.46μg/ml on average and was higher than the serum concentration (0.72±0.21μg/ml), the tissue/serum ratio (2.24) was significant. The tissue concentration of OFLX was higher than that of lomefloxacin and tosufloxacin. In addition, clinical and bacteriological trials on patients with otorhinolaryngological infections was carried out. OFLX was administered orally at a dose 600mg for more than three days. The incidence of stains resistant to OFLX (MIC>3.13μg/ml) was 5.8%. The overall clinical efficacy rate was 86.7% and there were no safety problems. It was concluded that OFLX is a useful drug for treating otorhinolaryngological infections.