ワルダイエル輪原発非ポジキンリンパ腫I,II期症例の検討

概要

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Between 1982 and 1983,42 patients with clinical Stage I or II non-Hodgkin's lymphomas of Waldeyer's ring were treated at our department. In eleven Stage I patients treated with radiation alone, both five-year survival and relapse-free survival rates were 100%. In 31 Stage II patients treated with chemotherapy (ACOP or CHOP) and radiation, these rates were 75.8% and 72.3%, respectively. In Stage IC patients, poor survival was significantly correlated with cervical lymph nodes greater than 6 cm in diameter. Prognosis for Stage II cases improved with the recent protocol for chemotherapy preceding radiation (5-year survival rates in the chemotherapy-preceding group and radiation-preceding group were 90.9% and 63.7%). Seven patients died of disease. The mean age of these patients was 70.3-yrs and mean survival time was 12.4 M. Six of the seven who died were treated with radiation prior to chemotherapy, and six cases had bulky lymph nodes or tumor. In conclusion, treatment with radiation alone is adequate for cases of Stage I NHL, and combination of chemotherapy and radiation is adequate for cases of Stage IC. In addition, intensive and short duration chemotherapy is necessary for patients with poor prognosis, especially those with bulky mass.
耳鼻咽喉科臨床学会の論文