Population based cohort study for Pediatric Infectious Diseases research in Vietnam

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概要

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• A population-based cohort study on pediatric infectious diseases was established at Khanh Hoa Province, central Vietnam in 2006, to determine the etiology and risk factors for severe pediatric infectious diseases (SPID) such as acute respiratory infection (ARI), diarrhea and dengue which are the major causes of under 5 mortality. A population census survey was conducted in Nha-Trang and Ninh-Hoa to collect demographic, social-behavioral data and disease burden on SPID. The study site covered a population of 353,525 residing in 75,826 households with 24,781 children less than 5 years. Hospital databases from two hospitals covering the region were obtained. Linking the census and hospital databases, we were able to investigate on a variety of SPID such as environmental tobacco smoking exposure and increased risked of pediatric pneumonia hospitalization, population density, water supply and risk of dengue fever and animal livestock and risk of hospitalized diarrhea. To determine incidence, viral etiology and risk factors for pediatric ARI/pneumonia, we setup a population based prospective hospitalized Pediatric ARI surveillance at Khanh Hoa General Hospital, Nha-Trang in February 2007. The study has revealed RSV, rhinovirus and influenza A as major viral pathogens, role of multiple viral infection and its interaction with bacteria in the development of pneumonia. In addition, we are also conducting a birth cohort study to investigate the incidence of congenital infection and its impact on physical-neurological development, and role of host genetic polymorphism on SPID hospitalization in Vietnam. Population mobility, high cost of regular census update and low mortality are the challenges.

• 日本熱帯医学会の論文

著者

• Thiem Vu

  National Institute Of Hygiene And Epidemiology

• Anh Nguyen

  National Institute Of Hygene And Epidemiology

• Yasunami Michio

  Institute Of Tropical Medicine (nekken) Nagasaki University

• Miyakawa Masami

  Department Of Industrial Engineering And Management Tokyo Institute Of Technology

• Moriuchi Hiroyuki

  Department Of Molecular Microbiology And Immunology Nagasaki University Graduate School Of Biomedica

• Takahashi Kensuke

  Institute of Technology and Science, The University of Tokushima, Tokushima 770-8506, Japan

• Ai Nguyen

  Khanh Hoa General Hospital

• Anh Dang Duc

  National Institute of Hygiene and Epidemiology

• Smith Wolf

  London School of Tropical Medicine and Hygiene

• Huong Vu

  National Institute of Hygiene and Epidemiology

• Yoshida Lay-Myint

  Institute of Tropical Medicine, Nagasaki University

• Suzuki Motoi

  Institute of Tropical Medicine, Nagasaki University

• Tsuzuki Ataru

  Institute of Tropical Medicine, Nagasaki University

• Watanabe Kiwao

  Institute of Tropical Medicine, Nagasaki University

• Tho Le Huu

  KhanhHoa Provincial Public Health Service

• Kilgore Paul

  College of Pharmacy and Health Sciences, Wayne State University

• Yoshino Hiroshi

  Institute of Tropical Medicine, Nagasaki University

• Toizumi Michiko

  Institute of Tropical Medicine, Nagasaki University

• Ariyoshi Koya

  Institute of Tropical Medicine, Nagasaki University

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