Dasatinib-responsive Chronic Lymphocytic Leukemia in a Patient Treated for Coexisting Chronic Myeloid Leukemia
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概要
- 論文の詳細を見る
We herein present a case of concurrent chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL). Two different clones, a Philadelphia (Ph) clone and a CLL clone with a 13q deletion, were identified using fluorescent in situ hybridization. Dasatinib was administered to inhibit Bcr-Abl and Lyn kinase. The patient exhibited a molecular response for CML and a partial response for CLL. To our knowledge, this is the first report to describe the occurrence of a gradual increase in the Bcr-Abl transcript level prior to the diagnosis of Ph-positive CML in an individual with CLL who was successfully treated with dasatinib as the first-line therapy.
- 社団法人 日本内科学会の論文
著者
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Sawada Kenichi
Department Of Hematology Nephrology And Rheumatology Akita University Graduate School Of Medicine
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Kume Masaaki
Department Of Internal Medicine Iii Akita University School Of Medicine
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Ohyagi Hideaki
Department Of Hematology Nephrology And Rheumatology Akita University Graduate School Of Medicine
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Takahashi Naoto
Department Of Anesthesiology University Of California San Diego School Of Medicine
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Shinohara Yoshinori
Department Of Physics Gakushuin University
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Kameoka Yoshihiro
Department Of Hematology Nephrology And Rheumatology Akita University Graduate School Of Medicine
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Noguchi Shinsuke
Department Of Hematology Sapporo Hokuyu Hospital
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Kameoka Yoshihiro
Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan
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Noguchi Shinsuke
Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan
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Nagao Takayo
Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan
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Shinohara Yoshinori
Department of Hematology, Hiraka General Hospital, Japan
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Kume Masaaki
Department of Hematology, Hiraka General Hospital, Japan
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