Tolvaptan Can Improve Clinical Course in Responders:Validation Analysis for the Definition of Responsiveness by Urine Volume
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概要
- 論文の詳細を見る
We previously defined "responders" as patients with increases in urine volume (UV) on day 1 after the administration of tolvaptan (TLV), and demonstrated that responders to TLV could be predicted with considerable accuracy by urine osmolality (U-OSM) levels. Responders and non-responders to TLV should be associated with different clinical courses after a certain time following TLV administration. Therefore, the aim of the present study was to validate our definition of responders by clinical parameters 1 week after administration of TLV. Data (<I>n</I> = 85) were obtained from inhospital patients with decompensated heart failure (HF) who had received TLV at 3.75-15 mg daily, and clinical data at 1 week after the administration of TLV were compared with those of baseline. Sixty patients (70.6%) were "responders", in whom UV on day 1 increased after the administration of TLV compared with day 0. "Non-responders" were older, and had higher serum creatinine concentration and lower baseline U-OSM than "responders". Serum creatinine concentration increased significantly in "non-responders", but was unchanged in "responders". Body weight, plasma B-type natriuretic peptide concentration, and HF symptom score decreased significantly in "responders", but remained unchanged in "non-responders". Increases in UV after the first administration of TLV were closely correlated with improvement of congestive HF after 1 week of TLV treatment, which verifi ed our defi nition of "responders" to TLV.
- International Heart Journal刊行会の論文
著者
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Inaba Toshiro
Department Of Cardiology The Cardiovascular Institute
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Hatano Masaru
Department Of Cardiology Narita Red Cross Hospital
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Kato Naoko
Department Of Anesthesiology Aichi Gakuin University School Of Dentistry
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Kinugawa Koichiro
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Yao Atsushi
Department Of Cardiology Tokyo University Hospital
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Maki Hisataka
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Komuro Issei
Department Of Cardiovascular Medicine
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Imamura Teruhiko
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Muraoka Hironori
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine
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Minatsuki Shun
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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Kato Naoko
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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Muraoka Hironori
Department of Cardiology, JR Tokyo General Hospital
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