Successful Conversion to Everolimus After Cytomegalovirus Infection in a Heart Transplant Recipient
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概要
- 論文の詳細を見る
Cytomegalovirus (CMV) infection remains a major problem in recipients with heart transplantation (HTx), because it may play a significant role in the development of cardiac allograft vasculopathy, which is one of the major causes of death after HTx. Valganciclovir (VGC) is effective for the treatment of CMV infection, but is often associated with neutropenia, especially when used with mycophenolate mophetil (MMF). We experienced an HTx recipient with positive CMV antigenemia who suffered progressive neutropenia after administration of VGC. We switched MMF to everolimus (EVL) and assay for CMV antigenemia was constantly negative even after discontinuation of VGC. In all other 14 HTx recipients who received EVL for any reason, we found that assay for CMV antigenemia remained negative throughout the period of EVL administration. Considering the prophylactic effect on CMV, EVL can not only be an alternative to rescue from comorbidity, but might also be indicated earlier especially in CMV-seronegative HTx recipients.
著者
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Inaba Toshiro
Department Of Cardiology The Cardiovascular Institute
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Hirata Yasunobu
Department Of Advanced Clinical Science And Therapeutics Cardiovascular Medicine Graduate School Of
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Shiga Taro
Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo
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Endo Miyoko
Department Of Bacteriology Tokyo Metropolitan Research Laboratory Of Public Health
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Hatano Masaru
Department Of Cardiology Narita Red Cross Hospital
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Kato Naoko
Department Of Anesthesiology Aichi Gakuin University School Of Dentistry
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Kinugawa Koichiro
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Yao Atsushi
Department Of Cardiology Tokyo University Hospital
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Nagai Ryozo
Department Cardiovascular Medicine The University Of Tokyo Hospital
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Maki Hisataka
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Imamura Teruhiko
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Inaba Toshiro
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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Yao Atsushi
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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Endo Miyoko
Department of Organ Transplantation, The University of Tokyo Hospital
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