Effect of Diffusive Direction across the Skin on the Penetration Profile of Chemicals in Vitro
スポンサーリンク
概要
- 論文の詳細を見る
Skin has various types of transporters and is a biochemically active organ. These aspects of skin influence the distribution of chemicals in skin and their elimination from skin. The biochemical and histological variations of the skin must be taken into account when conducting transdermal penetration research. Here we used hairless mouse skin to investigate the percutaneous absorption of chemicals in vitro from the stratum corneum (SC) side to the viable skin (VS) side (forward direction) and from the VS side to the SC side (backward direction). We examined the effects of molecular weight, lipophilicity (Log Ko/w), electric charge, and the molecular structure of penetrants. The penetration flux of verapamil hydrochloride (VRP) for the backward direction was 3.2 times larger than that for the forward direction. The flux values of benzoic acid (BA) and para-hydroxybenzoic acid (pHBA) for the forward direction were 2.1 and 4.6 times larger than those for the backward direction, respectively. This directional difference was caused by the active transporter for VRP, the histological distribution of BA solubility, and the intermolecular hydrogen bonding between pHBA and skin tissue in the stripped skin. Across intact skin, in contrast, there was no difference in the skin penetration profile between the forward direction and backward directions.
著者
-
Hikima Tomohiro
Department Of Biochemical Engineering And Science Kyushu Institute Of Technology
-
Tojo Kakuji
Department Of Biochemical Engineering And Science College Of Computer Science And Systems Engineerin
-
Hikima Tomohiro
Department of Bioscience and Bioinformatics, Kyushu Institute of Technology
-
Morofuji Ryo
Department of Bioscience and Bioinformatics, Kyushu Institute of Technology
関連論文
- Intravitreous Delivery of Dexamethasone Sodium m-Sulfobenzoate from Poly(DL-Lactic Acid) Implants
- Polymer Blend Implant for Ocular Delivery of Fluorometholone
- EFFECT OF ULTRASOUND ON RATE OF DRUG ABSORPTION THROUGH SKIN
- Skin Penetration Enhancement by the Synergistic Effect of Supersaturated Dissolution and Chemical Enhancers
- Effect of Supersaturated Dissolution and Crystallization on In Vitro Skin Penetration of 17-β-Estradiol from Acrylic Pressure Sensitive Adhesives
- Prediction of Plasma Concentration of GTS-21 in Hairless Rats Following Monolithic Transdermal Delivery
- PERIODIC CONTROL OF RATE OF DRUG PERMEATION THROUGH THE SKIN WITH IONTORHORESIS
- Skin Penetration Flux and Lag-Time of Steroids Across Hydrated and Dehydrated Human Skin in Vitro(Biopharmacy)
- Mucoadhesive Properties of Chitosan-Coated Ophthalmic Lipid Emulsion Containing Indomethacin in Tear Fluid
- Surface Dissolution-Bulk Erosion Model of Drug Release from Biodegradable Polymer Rods
- Prediction of Percutaneous Absorption in Human Using Three-Dimensional Human Cultured Epidermis LabCyte EPI-MODEL
- GAS HOLDUP AND PRESSURE DROP IN A MULTISTAGE VIBRATING DISK COLUMN WITH COCURRENT GAS-LIOUID FLOW
- Effect of Diffusive Direction across the Skin on the Penetration Profile of Chemicals in Vitro
- MASS TRANSFER IN A MULTISTAGE VIBRATING DISK COLUMN WITH COCURRENT GAS-LIQUID FLOW
- THE EFFECT OF THE WAVE FORM OF DISK VIBRATION ON MASS TRANSFER IN A MULTISTAGE VIBRATING DISK COLUMN WITH COUNTERCURRENT LIQUID-LIQUID FLOW
- LIQUID-PHASE MIXING IN A MULTISTAGE VIBRATING-DISK COLUMN WITH CONCURRENT GAS-LIQUID FLOW
- Release and permeation kinetics of matrix-type transdermal delivery systems for verapamil.