Intravitreous Delivery of Dexamethasone Sodium m-Sulfobenzoate from Poly(DL-Lactic Acid) Implants
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概要
- 論文の詳細を見る
Biodegradable intravitreal rod-shaped implants containing dexamethasone sodium m-sulfobenzoate (DMSB) were prepared from blends of poly(DL-lactic acid) (PLA) with number-average molecular weight 2000 (PLA2000) and 4000 (PLA4000). The effect of the fraction of PLA2000 on the release of DMSB from the implant was investigated after implantation in the vitreous body of rabbit eyes. After the initial burst, the drug was released slowly from the blended PLA implants with a PLA2000 fraction of below 30 wt% in normal eyes within a period of 28 d. For the implants with a higher PLA2000 fraction of over 50 wt%, the drug was released following approximately first order kinetics. In the vitrectomized eyes, the release of DMASB from the PLA2000/PLA4000 (5/5) implant was 2.5 times more rapid than in normal eyes, and the clearance of drug was also appreciable accelerated as compared with that in normal eyes.
- 社団法人日本薬学会の論文
- 1998-02-15
著者
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Kimura Masako
Kobe Creative Center Senju Pharmaceutical Co. Ltd.
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Morita Yasushi
Kobe Creative Center Senju Pharmaceutical Co. Ltd.
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OHTORI Akira
Kobe Creative Center, Senju Pharmaceutical Co., Ltd.,
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TOJO Kakuji
Department of Biochemical Science and Engineering, College of Computer Science and Biosystems Engine
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Tojo Kakuji
Department Of Biochemical Engineering And Science College Of Computer Science And Systems Engineerin
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Ohtori Akira
Kobe Creative Center Senju Pharmaceutical Co. Ltd.
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Tojo Kakuji
Department Of Biochemical Science And Engineering College Of Computer Science And Biosystems Enginee
関連論文
- Intravitreous Delivery of Dexamethasone Sodium m-Sulfobenzoate from Poly(DL-Lactic Acid) Implants
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