Drug Delivery to the Eye with a Transdermal Therapeutic System(Biopharmacy)
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概要
- 論文の詳細を見る
A matrix-type transdermal therapeutic system was developed for treating diseases of the eye where it is difficult for drug molecules to reach with conventional topical instillation. Prednisolone was employed as a model drug. An in vivo study using rats showed that the daily application of the patch maintained a constant plasma concentration of the drug, which was equivalent the therapeutic plasma level following three times daily oral administration (30 mg), for approximately 24 h. Transdermal delivery provided equivalent to or higher bioavailability (drug distribution) to the eyeball of topical administration. Moreover, pharmacokinetic analysis indicated that the present transdermal therapeutic system may be clinically effective as a new treatment for ocular diseases.
- 公益社団法人日本薬学会の論文
- 2003-01-01
著者
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Tojo K
Kyushu Inst. Of Technol. Fukuoka Jpn
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Ohtori Akira
Faculty Of Pharmaceutical Sciences Kinki University
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Ohtori A
Kobe Creative Center Senju Pharmaceutical Co. Ltd.
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Ohtori Akira
Kobe Creative Center Senju Pharmaceutical Co. Ltd.
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Matsuda Y
College Of Computer Science And Systems Engineering Kyushu Institute Of Technology
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Tojo Kakuji
College Of Computer Science And Systems Engineering Kyushu Insitute Of Technology
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ISOWAKI Akiharu
Kobe Creative Center, Senju Pharmaceutical Co., Ltd.
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MATSUO Yumi
College of Computer Science and Systems Engineering, Kyushu Institute of Technology
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