Development of a Stick-Type Transdermal Eyelid Delivery System of Ketotifen Fumarate for Ophthalmic Diseases
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概要
- 論文の詳細を見る
A transdermal eyelid delivery system for treating ocular diseases (eye-stick) has been developed. Ketotifen fumarate (KT) was used as a model drug. An in vivo study using rabbits showed that the eye-stick device maintained a constant conjunctival concentration of the drug for an extended period of time, which was equivalent or higher than the therapeutic level following eye drop administration. Moreover, the conjunctival concentration after eye-stick application was well predicted using the physicochemical parameters, diffusion coefficient and partition coefficient, obtained from in vitro hairless mouse skin permeation experiments.
- 公益社団法人日本薬学会の論文
- 2007-07-01
著者
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Tojo Kakuji
College Of Computer Science And Systems Engineering Kyushu Institute Of Technology
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KIMURA Chiharu
College of Computer Science and Systems Engineering, Kyushu Institute of Technology
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Tojo Kakuji
College Of Computer Science And Systems Engineering Kyushu Insitute Of Technology
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Kimura Chiharu
College Of Computer Science And Systems Engineering Kyushu Institute Of Technology
関連論文
- Control of the Barrier Capacity of Stratum Corneum by Microdermabrasion
- Synergistic Effect of Sonophoresis and Iontophoresis in Transdermal Drug Delivery
- Development of a Stick-Type Transdermal Eyelid Delivery System of Ketotifen Fumarate for Ophthalmic Diseases
- Effect of Microdermabrasion on Barrier Capacity of Stratum Corneum
- In Vivo/In Vitro Correlation of Intravitreal Drug Delivery from Biodegradable Polymer Implants
- Drug Delivery to the Eye with a Transdermal Therapeutic System(Biopharmacy)