Polymer Blend Implant for Ocular Delivery of Fluorometholone
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概要
- 論文の詳細を見る
Ocular implants containing fluorometholone (FLM) were prepared using blends of poly (DL-lactic acid) (PLA) and polyvinyl pyrrolidone (PVP). The effect of the fraction of PVP content on the release of FLM from the implant was investigated in vitro. The drug was released from the device by approximately following first order kinetics within the period of 40d. The release rate gradually increased with an increase in the PVP content. The in vivo study after implantation in the anterior chamber of rabbit eyes indicated that the PLA-PVP implant showed a good correlation between the in vitro and in vivo release of FLM. The present polymer blend implant demonstrated a constant level of FLM in the aqueous humor for one month.
- 社団法人日本薬学会の論文
- 1998-01-15
著者
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Morita Yasushi
Kobe Creative Center Senju Pharmaceutical Co. Ltd.
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TOJO Kakuji
Department of Biochemical Science and Engineering, College of Computer Science and Biosystems Engine
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SAINO Hiroko
Kobe Creative Center, Senju Pharmaceutical Co., Ltd.,
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Tojo Kakuji
Department Of Biochemical Engineering And Science College Of Computer Science And Systems Engineerin
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Tojo Kakuji
Department Of Biochemical Science And Engineering College Of Computer Science And Biosystems Enginee
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Saino Hiroko
Kobe Creative Center Senju Pharmaceutical Co. Ltd.
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