Surface Dissolution-Bulk Erosion Model of Drug Release from Biodegradable Polymer Rods
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概要
- 論文の詳細を見る
A combined model of surface dissolution of the drug and bulk erosion of the polymer is developed for describing the biphasic release profile of drugs from biodegradable polymer rod devices. The model parameters are determined from the conventional moment analysis of the time course of the release profile. The model describes well the typical biphasic phenomena of drug release, the initial bursting release due to dissolution of the surface drug molecules, and the late bursting caused by the bulk erosion of biodegradable polymers.
- 社団法人 化学工学会の論文
著者
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Tojo K
Department Of Biochemical Engineering And Science Kyushu Institute Of Technology
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Tojo Kakuji
Department Of Biochemical Engineering And Science College Of Computer Science And Systems Engineerin
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Aoyagi Hisae
Department Of Biochemical Science And Engineering Kyushu Institute Of Technology Iizuka Campus
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KURITA Tomonori
Department of Biochemical Science and Engineering, Kyushu Institute of Technology, Iizuka Campus
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Kurita Tomonori
Department Of Biochemical Science And Engineering Kyushu Institute Of Technology Iizuka Campus
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