Relationship between Methyl CpG Binding Protein 2 and JC Viral Proteins
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概要
- 論文の詳細を見る
JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.
著者
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Nagashima Kazuo
Department Of Cellular Pathology Graduate School Of Medicine Hokkaido University
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Tsuda Masumi
Department Of Environmental Medicine And Informatics Graduate School Of Environmental Earth Science
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Wang Lei
Department Of Cardio-thoracic Surgery Xinhua Hospital School Of Medicine Shanghai Jiaotong Universit
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Nishihara Hiroshi
Department Of Chemistry Faculty Of Science And Technology Keio University
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TAKAHASHI Kenta
Department of Pathology, Laboratory of Cancer Research, Hokkaido University Graduate School of Medicine
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NAGASHIMA Kazuo
Department of Pathology, Sapporo Higashi-Tokushukai Hospital
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Sawa Hirofumi
Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University
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TANAKA Shinya
Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University
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Tanino Mishie
Department of Cancer Pathology, Hokkaido University Graduate School of Medicine
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Orba Yasuko
Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University
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Kimura Taichi
Department of Cancer Pathology, Hokkaido University Graduate School of Medicine
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Kohsaka Shinji
Department of Cancer Pathology, Hokkaido University Graduate School of Medicine
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Takahashi Kenta
Department of Cancer Pathology, Hokkaido University Graduate School of Medicine
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Tsuda Masumi
Department of Cancer Pathology, Hokkaido University Graduate School of Medicine
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