Characteristic Features of Female Pattern Hair Loss and the Improvement by Adenosine

概要

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Most common hair loss in women is classified as "female pattern hair loss (FPHL)", and it is distinguished from androgenetic alopecia (AGA) in men. The fronto-temporal recession is typical and prominent in AGA, whereas FPHL is characterized by a diffuse reduction in hair density in the wider area of central scalp and the frontal hairline is usually preserved. Adenosine has been shown to be effective in thickening hair shafts and improve the condition in AGA in men. Here we studied the efficacy of adenosine treatment to improve hair loss in women. After 12 months' application of lotion containing adenosine, significant increase in the thick hair ratio was observed as compared with a placebo control. Furthermore, adenosine lotion supplemented with Panax ginseng increased in hair density and thick hair ratio in 6 months' use as compared with before use. No adverse effects were encountered during the trials. These data suggest adenosine is valuable as a safe and effective hair-growth promoting ingredient to improve the quality of life (QOL) for women as well as for men.