Risk Factors for Tumor Recurrence after Curative Resection in Patients with Stage IIIa Colon and Rectosigmoid Cancer

概要

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The aim of this study was to clarify the risk factors associated with recurrence in Stage IIIa colon and rectosigmoid cancer. Method: A retrospective review of 236 cases of grossly radical colectomy for Stage IIIa colon and rectosigmoid cancer during the period between 1990 and 2007.<BR>Results: The overall recurrence rate was 22.0% (52/236 cases). Univariate analysis identified three risk factors for recurrence: preoperative CEA (>=5.0 ng/m<I>l</I>) (p=0.033), size of tumor (>=40mm) (p=0.042), and depth of tumor invasion (>=SE) (p=0.008). Multivariate analysis selected three dependent risk factors for recurrence: presence of venous invasion, presence of lymphatic invasion, and depth of tumor invasion (>=SE) (HR 1.830, 2.316, 2.156, 95% CI 1.009-3.320, 1.206-4.449, 1.204-3.863, p=0.0467, 0.0117, 0.0098). Conclusion: This study suggested that we should consider active postoperative adjuvant chemotherapy such as oxaliplatin for Stage IIIa colon and rectosigmoid cancer with venous invasion, lymphatic invasion, or tumor depth of SE or SI.