Is Plasma Alpha-Tocopherol Associated with Electronegative LDL in Obese Adolescents?
スポンサーリンク
概要
- 論文の詳細を見る
Obesity has increased in children and adolescents. What is reflected in the early occurrence of cardiometabolic alterations, like hypertension and type 2 diabetes, where the oxLDL formation is stimulated. Various studies have shown that plasma α-tocopherol (α-TP) can protect LDL against oxidation. Nevertheless, the action of plasma α-TP in cardiovascular diseases remains controversial. We conducted a cross-sectional study to evaluate plasma α-TP and its impact on the concentration of LDL(−). Adolescents (n=150) of both sexes were classified into three groups: healthy weight (HW; 50%), overweight (OV; 22%), and obese (OB; 28%). Lipid profile, LDL(−), anti-oxLDL and anti-LDL(−) antibodies, CRP (ELISA) and plasma α-TP (HPLC) were analyzed. Demographic, anthropometric, and food intake data were evaluated. Crude and energy-adjusted intake of vitamin E in the OB group were higher than in the HW group (p<0.001). Crude and energy-adjusted vitamin E intakes were not correlated with plasma α-TP (r=−0.07; p=0.412 and r=−0.064; p=0.467, respectively). Subjects in the OB group had higher TC and LDL-C and lower HDL-C than in the HW and OV groups. C-reactive protein and anti-oxLDL antibodies changed as a function of BMI. The impact of obesity was reinforced by high values for LDL(−) and low content of plasma α-TP in comparison with the HW (p<0.001) and OV groups (p=0.03). This negative profile was maintained for the ratio between α-TP and TC or LDL-C. Plasma α-TP, α-TP/TC and α-TP/LDL-C were negatively associated with LDL(−) and other cardiometabolic risk factors (BMI, WC, AC and anti-oxLDL). Our results demonstrate that obesity in adolescents is associated with high levels of LDL(−) and low plasma α-TP content.
著者
-
Da Silva
Departamento De Biologia Celular Universidade De Brasilia
-
SILVA Isis
Department of Nutrition, School of Public Health, University of São Paulo
-
DAMASCENO Nágila
Department of Nutrition, School of Public Health, University of São Paulo
-
MELLO Ana
Department of Nutrition, School of Public Health, University of São Paulo
-
ABDALLA Dulcineia
Department of Clinical Analysis and Biochemistry, Faculty of Pharmaceutical Sciences, University of São Paulo
-
SANCHES Letícia
Department of Nutrition, School of Public Health, University of São Paulo
関連論文
- Finite element analysis of weakened roots restored with composite resin and posts
- Improved Microwave-Mediated Synthesis of 3-(3-Aryl-1,2,4-oxadiazol-5-yl)propionic Acids and Their Larvicidal and Fungal Growth Inhibitory Properties
- Advances and perspectives in Leishmania cell based drug-screening procedures
- Chemical constituents from leaves of Palicourea coriacea (Rubiaceae)
- Brain Activation During Intermittent Photic Stimulation : A [^O]-Water PET Study on Photosensitive Epilepsy
- Flavonoids and a Naphthopyranone from Eriocaulon ligulatum and Their Mutagenic Activity
- A phylogenetic study of hepatitis B virus in chronically infected Brazilian patients of Western and Asian descent
- Evaluation of Strychnos pseudoquina ST. HIL. Leaves Extract on Gastrointestinal Activity in Mice
- アマゾン浸水域のバルゼア林とテラフィルメ林の特性
- Intracranial EEG Seizure-Offset Termination Patterns : Relation to Outcome of Epilepsy Surgery in Temporal Lobe Epilepsy
- Identification of Frontal Lobe Epileptic Foci in Children Using Positron Emission Tomography
- Efficacy and tolerability of long-term therapy using high lamivudine doses for the treatment of chronic hepatitis B
- Spontaneous hepatitis B surface antigen clearance in a long-term follow-up study of patients with chronic type B hepatitis. Lack of correlation with hepatitis C and D virus superinfection
- Embryonal rhabdomyosarcoma of the uterus associated with uterine inversion in an adolescent : A case report and published work review
- Radiation Hardness of Epitaxial and Non-Epitaxial 6H-SiC MOS Capacitors
- Partitioning of caseinomacropeptide in aqueous two-phase systems
- Vocalisations of wild common marmosets are influenced by diurnal and ontogenetic factors
- In Vitro Proliferation and Osteoblastic Phenotype Expression of Cells Derived From Human Vertebral Lamina and Iliac Crest
- Physical exercise during the adolescent period of life increases hippocampal parvalbumin expression
- Management of Wilms' tumor with intracardiac extension
- Simple immunoaffinity method to purify recombinant hepatitis B surface antigen secreted by transfected mammalian cells
- Behavioral and hormonal response of common marmosets, Callithrix jacchus, to two environmental conditions
- Antiedematogenic Activity of Two Thiazolidine Derivatives: N-Tryptophyl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)Rhodanine (GS26) and N-Tryptophyl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2,4-thiazolidinedione (GS28)
- Stochastic dynamics in exotic and native blowflies : an analysis combining laboratory experiments and a two-patch metapopulation model
- Effect of Soaking Prior to Cooking on the Levels of Phytate and Tannin of the Common Bean (Phaseolus vulgaris, L.) and the Protein Value
- P-161 EFFECT OF SOME COUMARINS, FLAVONOIDS AND LIMONOIDS ON THE GROWTH OF XYLELLA FASTIDIOSA
- Differential GABA_A Subunit Expression Following Status Epilepticus in Seizure-prone and Seizure-resistant Rats : A Putative Mechanism for Refractory Drug Response
- Chemical and Immunological Characterization of a Low Molecular Weight Outer Membrane Protein of Salmonella typhi
- Commission on Outcome Measurement in Epilepsy, 1994-1997 : Final Report
- Partition of α-lactoalbumin and β-lactoglobulin by cloud point extraction
- Development and validation of a capillary zone electrophoresis method for assessment of recombinant human granulocyte colony-stimulating factor in pharmaceutical formulations and its correlation with liquid chromatography methods and bioassay
- Determination of Manganese in Urine and Whole Blood Samples by Electrothermal Atomic Absorption Spectrometry : Comparison of Chemical Modifiers
- Antinociceptive properties of conocarpan and orientin obtained from Piper solmsianum C. DC. var. solmsianum (Piperaceae)
- Nuclear and environment morphometric profile in tumor size and nodal metastasis of resected typical pulmonary carcinoid
- Nuclear markers (star volume, mitotic index, AgNOR and Ki-67) of the primary tumor and its metastasis in non-small cell lung carcinomas
- Distribution of potential suitable hammers and transport of hammer tools and nuts by wild capuchin monkeys
- Interaction between egocentric and exocentric frames of reference assessed by perceptual constancy parameters (特集:空間の知覚と認知のモデル)
- Isolation and Structure Determination of Bioactive Isoflavones from Callus Culture of Dipteryx odorata
- A Comparison of Mycolic Acid Analysis for Nontuberculous Mycobacteria Identification by Thin-Layer Chromatography and Molecular Methods
- A Novel Micellar Medium Using Triblock Copolymer for Cobalt Determination
- Diffusely Adhering Escherichia coli (DAEC) Strains of Fecal Origin Rarely Express F1845 Adhesin
- Resin tag length of one-step and self-etching adhesives bonded to unground enamel
- Expanded bed adsorption of an alkaline lipase from Pseudomona cepacia
- Reduction of the number of nuclei per cell of Helminthosporium euphorbiae by protoplast isolation
- Thermodynamic studies of partitioning behavior of lysozyme and conalbumin in aqueous two-phase systems
- B23-089 MICRO THERMOELECTRIC COOLER : INTERFACIAL EFFECTS, OPTIMIZATION AND FABRICATION
- Inhibitory effects of ginger (Zingiber officinale Roscoe) essential oil on leukocyte migration in vivo and in vitro
- Dentin-induced in vivo Inflammatory Response and in vitro Activation of Murine Macrophages
- Letter to the Editor
- Processes that Intervene in the Generation of the Photoacoustic Effect in Alkali Halides with F-Centers
- Occurrence of Multidrug-Resistant and Toxic-Metal Tolerant Enterococci in Fresh Feces from Urban Pigeons in Brazil
- Additive diuretic response of concurrent aminophylline and furosemide in children : a case series and a brief literature review
- Synthesis, Antitumor, Antitrypanosomal and Antileishmanial Activities of Benzo[4,5]canthin-6-ones Bearing the N′-(Substituted benzylidene)-carbohydrazide and N-Alkylcarboxamide Groups at C-2
- X-Ray Radiation Response of Epitaxial and Nonepitaxial n-6H–SiC Metal-Oxide-Semiconductor Capacitors
- Is Plasma Alpha-Tocopherol Associated with Electronegative LDL in Obese Adolescents?
- Relaxant effect of Ent-7α-hydroxytrachyloban-18-oic acid, a trachylobane diterpene from Xylopia langsdorfiana A. St-Hil. & Tul., on tracheal smooth muscle
- Karyotype description of three sympatric species of Astyanax (Characiformes, Characidae)
- Heparanase expression and glycosaminoglycans profile in renal cell carcinoma
- Karyotype description of three sympatric species of Astyanax (Characiformes, Characidae)
- Radiopacity, pH and antimicrobial activity of Portland cement associated with micro- and nanoparticles of zirconium oxide and niobium oxide