Acute Kidney Injury in a Patient with Nephrotic Syndrome due to Focal Segmental Glomerular Nephritis Induced by a Single Oral Administration of High-dose Bisphosphonate (Minodronate)
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概要
- 論文の詳細を見る
We herein report the case of a 75-year-old man who developed an increased serum creatinine level (4.93 mg/dL) and oliguria with massive proteinuria (7.14 g/day) on the second day after a single oral administration of high-dose (56 mg) minodronate. The histology of a renal biopsy showed one area of glomerular sclerosis among 20 glomeruli with global foot process effacement of podocytes and mild infiltration of lymphocytes and eosinophils into the interstitial space. Acute kidney injury in nephrotic syndrome due to focal segmental glomerular sclerosis induced by minodronate was diagnosed. Following cessation of minodronate without the administration of immunosuppressive agents, the patient's renal function and proteinuria markedly improved.
著者
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Akimoto Tetsu
Division Of Nephrology Department Of Internal Medicine Jichi Medical School
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Kobayashi Takahisa
Division Of Nephrology Department Of Medicine Jichi Medical School Department Of Nephrology Jichi Me
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Kusano Eiji
Division Of Nephrology Department Of Internal Medicine Jichi Medical School
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Muto Shigeaki
Division Of Nephrology Department Of Internal Medicine Jichi Medical School
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Morishita Yoshiyuki
Division Of Nephrology Department Of Medicine Jichi Medical University
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Yumura Wako
Division Of Nephrology Department Of Internal Medicine Jichi Medical University
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Ando Yasuhiro
Division Of Marine Life Sciences Faculty Of Fisheries Science Hokkaido University
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Yamamoto Hisashi
Division Of General Thoracic Surgery Department Of Surgery Keio University School Of Medicine
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Takemoto Fumi
Division Of Nephrology Department Of Internal Medicine Jichi Medical University
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Numata Akihiko
Division Of Nephrology Department Of Internal Medicine Jichi Medical University
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Iwazu Kana
Division Of Nephrology Department Of Internal Medicine Jichi Medical University
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Saito Osamu
Division Of Nephrology Department Of Internal Medicine Jichi Medical University
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Numata Akihiko
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
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Komada Takanori
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
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Kitamura Masafumi
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
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Yamamoto Hisashi
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
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Akimoto Tetsu
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
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Kobayashi Takahisa
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
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