An Adult Case of Fulminant Epstein-Barr Virus Infection with Acute Tubulointerstitial Nephritis
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概要
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Epstein-Barr virus (EBV) infection is common in adolescence, but fulminant infection is very rare. A 40-year-old man presented with high fever and sore throat. Symptoms, including cervical lymphadenopathy, jaundice, atypical lymphocytosis, respiratory distress and oliguria, suggested infectious mononucleosis with multiple organ failure that required mechanical ventilation and renal replacement therapy. Virus markers were consistent with primary EBV infection. Renal function was gradually improved by corticosteroid therapy. Renal biopsy revealed acute tubulointerstitial nephritis. In situ hybridizaion EBV-encoded RNA 1 did not show the presence of virus in the kidney, but acute kidney injury may be explained by cytotoxic/suppressor T lymphocyte infiltration,
著者
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Yoshida Izumi
Division Of Bio- And Geosciences Graduate School Of Science Osaka City University
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MORI Honami
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and
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Suzuki Jun
Division Of Cardiology Department Of Integrated Medicine And Informatics Ehime University Graduate S
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Tabei Kaoru
Division Of Integrated Medicine I Omiya Medical Center Jichi Medical School
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Tabei Kaoru
Division of Nephrology, Saitama Medical Center, Jichi Medical University, Japan
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Komada Takanori
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
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Tsuruoka Hirohisa
Division of Nephrology, Saitama Medical Center, Jichi Medical University, Japan
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Hirai Keiji
Division of Nephrology, Saitama Medical Center, Jichi Medical University, Japan
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