Epidemiology of Hantavirus Infection in Thousand Islands Regency of Jakarta, Indonesia
スポンサーリンク
概要
- 論文の詳細を見る
Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne zoonotic disease caused by hantavirus infection. Many HFRS cases have been reported in East Asia and North Europe, while the situation in Southeast Asia remains unclear. In this study, the prevalence of hantavirus infection in rodents and humans in Thousand Islands regency, which is close to the port of Jakarta, one of the largest historic ports in Indonesia, was investigated. A total of 170 rodents were captured in 2005, and 27 (15.9%) of the rodents were antibody-positive against Hantaan virus antigen in an immunofluorescence assay (IFA) and Western blotting. Despite the high prevalence in rodents, human sera collected from 31 patients with fever of unknown origin and 20 healthy volunteers in the islands in 2009 did not show positive reaction to the antigen in IFA. To identify the virus in rodents genetically, a total of 59 rodents were captured in 2009. Sera from the rodents were screened for antibody by ELISA, and lung tissues were subjected to RT-PCR. 20 (33.9%) of the 59 rodents were antibody-positive, and 3 of those 20 rodents were positive for S and M genome segments of hantaviruses. Genetic analysis showed that the viruses belonged to Seoul virus and formed a cluster with those in Vietnam and Singapore. These results suggest that a unique group of Seoul viruses has spread widely in Southeast Asia.
著者
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ENDO Rika
Department of Microbiology, Hokkaido University Graduate School of Medicine
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SHIMIZU Kenta
Department of Microbiology, Hokkaido University Graduate School of Medicine
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YASUDA Shumpei
Department of Microbiology, Hokkaido University Graduate School of Medicine
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KOMA Takaaki
Department of Microbiology, Hokkaido University Graduate School of Medicine
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ARIKAWA Jiro
Department of Microbiology, Graduate School of Medicine, Hokkaido University
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YOSHIMATSU Kumiko
Department of Microbiology, Graduate School of Medicine, Hokkaido University
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YASUDA Shumpei
Department of Microbiology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060–8638, Japan
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IBRAHIM Ima-Nurisa
National Institute of Health Research and Development, Ministry of Health, Jl. Percetakan Negra 29, Jakarta 10560, Indonesia
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YUNIANTO Andre
National Institute of Health Research and Development, Ministry of Health, Jl. Percetakan Negra 29, Jakarta 10560, Indonesia
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SALWATI Ervi
National Institute of Health Research and Development, Ministry of Health, Jl. Percetakan Negra 29, Jakarta 10560, Indonesia
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SHIMIZU Kenta
Department of Applied Chemistry, Chuo University
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