Successful Diet and Exercise Therapy as Evaluated on Self-Assessment Score Significantly Improves Endothelial Function in Metabolic Syndrome Patients
スポンサーリンク
概要
- 論文の詳細を見る
Background: Simple office-based counseling for diet and exercise does not appear to positively affect success rates in metabolic syndrome (MetS) patients. The utility of the lifestyle modification self-assessment score (Self-AS) in the improvement of endothelial function by office-based counseling for patients with MetS was investigated. Methods and Results: Patients with MetS (n=207) and age- and sex-matched individuals without MetS (n=124) were enrolled in this cross-sectional study. Endothelial function was assessed using reactive hyperemia-peripheral arterial tonometry index (RHI). Patients with MetS had significant endothelial dysfunction compared with those without MetS (RHI, 0.502±0.178 vs. 0.614±0.229; P<0.001). Seventy MetS patients participating in the prospective interventional study received simple office-based lifestyle modification counseling that was accompanied by Self-AS questionnaire after 10 months. RHI was significantly improved following lifestyle modifications (from 0.452±0.136 to 0.547±0.202, P<0.001). Reductions in waist circumference (R2=0.094, P=0.01) and increased high-density lipoprotein cholesterol (R2=0.227, P<0.001) independently correlated with improved RHI. Self-AS significantly correlated with changes in waist circumference (r=−0.57, P<0.001) and RHI (r=0.30, P=0.02). Patients with a good achievement of lifestyle modifications (higher Self-AS) had significant improvement in endothelial function compared with those with lower scores (% change in RHI, +48.7±61.6 vs. +7.8±35.1, P=0.001). Conclusions: Good achievement of lifestyle modifications as evaluated on Self-AS significantly improved endothelial function with concomitant reductions in waist circumferences in MetS patients.
著者
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Sugiyama Seigo
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
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Akiyama Eiichi
Department Of Cardiology Fujisawa Municipal Hospital
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Kimura Kazuo
Division Of Cardiology Yokohama City University Medical Center
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Sumida Hitoshi
Department Of Cardiology Kumamoto City Hospital
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Suzuki Hiroyuki
Division of Cardiology, Yokohama City University Medical Center
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Nakayama Naoki
Department Of Ecosystem Studies Graduate School Of Agricultural And Life Sciences The University Of
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Suzuki Hiroyuki
Division Of Cardiology Department Of Internal Medicine Showa University Fujigaoka Hospital
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Iwashita Satomi
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Ogawa Hisao
Department Cardiovascular Medicine Kumamoto University:division Of Intensive Care Unit Kumamoto Univ
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Sugamura Koichi
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Yamamuro Megumi
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Konishi Masaaki
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Umemura Satoshi
Department Of Internal Medicine Ii Yokohama City University School Of Medicine
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Matsuzawa Yasushi
Department Of Cardiology Kumamoto University School Of Medicine
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Jinnouchi Hideaki
Jinnouchi Clinic Diabetes Care Center
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UMEMURA Satoshi
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine
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Yamamuro Megumi
Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University
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Kurokawa Hirofumi
Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University
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Fujisue Koichiro
Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University
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Sumida Hitoshi
Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University
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Fujisue Koichiro
Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University
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Matsuzawa Yasushi
Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University
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Ogawa Hisao
Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University
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Akiyama Eiichi
Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University
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Sugamura Koichi
Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University
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Konishi Masaaki
Department of Biotechnology and Environmental Chemistry, Kitami Institute of Technology
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Kurokawa Hirofumi
Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University
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Nakayama Naoki
Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University
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