Expression Levels of Toll-Like Receptor Genes in Coronary Atherosclerotic Lesions of Patients With Acute Coronary Syndrome or Stable Angina Pectoris
スポンサーリンク
概要
- 論文の詳細を見る
Background: The differences between acute coronary syndrome (ACS) and stable angina pectoris (SAP) in Toll-like receptor (TLR) expression levels in coronary plaques are not well known. TLR gene expression levels were examined, not only in peripheral blood mononuclear cells (PBMCs), but also in coronary plaques in ACS and SAP patients. Methods and Results: TLR gene expression levels were examined in PBMCs using real-time RT-PCR in 27 ACS patients, 45 SAP patients and 28 control subjects. TLR2 and TLR4 expression levels in the PBMCs were significantly higher in the ACS group than in the SAP group. TLR9 expression levels were not significantly different among the 3 groups. TLR gene expression levels were also measured in directional coronary atherectomy (DCA) samples from 9 ACS and 14 SAP patients. The TLR2 expression levels in the DCA samples did not significantly differ between the 2 groups. The TLR4 expression levels were significantly higher in the ACS group than in the SAP group. Conclusions: The results suggest that TLR4 signaling could be more associated with plaque destabilization than with plaque progression. TLR4 expression control may be a novel target for ACS treatment. (Circ J 2009; 73: 1479 - 1484)
- 2009-07-20
著者
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Ogawa Hisao
Department of Cardiology, Kumamoto University
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Nakayama Masafumi
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Sugiyama Seigo
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Soejima Hirofumi
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Fukushima Ryuichiro
Department of Cardiovascular Medicine, Kumamoto University I
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Oe Yoko
Department of Cardiovascular Medicine, Kumamoto University I
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Oe Yoko
Graduate Sch of Medical Sciences, Kumamoto University
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Sugiyama Seigo
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Sugiyama Seigo
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
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Nakayama Masahumi
Department Of Cardiovasuclar Medicine Graduate School Of Medical Sciences Kumamoto University
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Nakayama Masafumi
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
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Ogawa Hisao
Kumamoto University
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Ogawa Hisao
Department Of Cardiovascular Medicine Kumamoto University Graduate School Of Medical Sciences
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Oshima Shuichi
Kumamoto Central Hospital
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Oshima Shuichi
Division of Cardiology, Kumamoto Central Hospital
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Nakayama Masahumi
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
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Oimatsu Hiroshi
札幌第一病院
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Fukunaga Takashi
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
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Ogawa Hisao
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Ogawa Hisao
Division Of Cardiology Health Insurance Hitoyoshi General Hospital
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Hisao Ogawa
Department Of Cardiovascular Medicine Kumamoto University Graduate School Of Medical Sciences
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Fukunaga Takashi
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Fukunaga Takashi
Department Of Cardiology Miyazaki Prefecture Miyazaki Hospital
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Soejima Hirofumi
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Soejima Hirofumi
Department Of Cardiology Kumamoto Chuo Hospital
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Ogawa Hisao
Department Cardiovascular Medicine Kumamoto University:division Of Intensive Care Unit Kumamoto Univ
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Nakayama Masafumi
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Oshima Shuichi
Division Of Cardiology Kumamoto Central Hospital
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Oe Yoko
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
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Fukushima Ryuichiro
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
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Oe Yoko
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Oimatsu Hiroshi
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Soejima Hirofumi
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
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Ooshima Shuuichi
Division Of Cardiology Kumamoto Central Hospital
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Sugiyama Seigo
Department Of Cardiovascular Medicine Kumamoto University School Of Medicine
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Nakayama Masafumi
Department of Cardiology, Tachikawa General Hospital, Japan
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