Fragmented QRS Predicts Cardiovascular Death of Patients With Structural Heart Disease and Inducible Ventricular Tachyarrhythmia
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概要
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Background: Fragmented QRS (fQRS) can predict cardiac events, and inducible ventricular tachycardia/fibrillation (VT/VF) is a known high-risk factor for arrhythmic death. However, whether fQRS is a predictor of cardiac events in patients with inducible VT/VF is unknown. We aimed to evaluate whether fQRS is a predictor of cardiac events in patients with structural heart disease and inducible VT/VF. Methods and Results: We retrospectively investigated 98 patients with structural heart disease who had a defibrillator device implanted. All patients underwent electrophysiological testing prior to or after device implantation and VT/VF was induced. fQRS was present in 30 patients. Appropriate defibrillator therapies were similar between the fQRS and non-fQRS groups (47% vs. 47%). In total, 25 patients (26%) died during a mean follow-up period of 87±43 months. All-cause mortality (12 [40%] vs. 13 [19%]) and cardiovascular deaths (9 [30%] vs. 4 [6%]) were significantly higher in the fQRS group than non-fQRS group, respectively; Kaplan-Meier analysis revealed significantly lower event-free survival for all-cause mortality (P=0.012) and cardiovascular deaths (P=0.001) for fQRS patients. A multivariable Cox regression model revealed that fQRS was an independent predictor of cardiovascular death (hazard ratio, 4.58; 95% confidence interval, 1.34–15.64; P=0.015). Conclusions: fQRS is a predictor of cardiovascular death in patients with structural heart disease and inducible VT/VF.
著者
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Sakurada Harumizu
Tokyo Ccu Network Scientific Committee
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Fukamizu Seiji
Department Of Cardiology Surugadai Nihon University Hospital
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Tanabe Yasuhiro
Department of Cardiology, Tokyo Metropolitan Hiroo Hospital
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Tejima Tamotsu
Department of Cardiology, Tokyo Metropolitan Hiroo Hospital
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Komiyama Kota
Department Of Allergy And Rheumatology Japanese Red Cross Medical Center Hospital
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Tejima Tamotsu
Department Of Cardiology Tokyo Metropolitan Hiroo General Hospital
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Nishizaki Mitsuhiro
Department Of Cardiology Yokohama Minami Kyosai Hospital
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Tanabe Yasuhiro
Department Of Cardiology Tokyo Metropolitan Hiroo General Hospital
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Hayashi Takekuni
Department Of Cardiology Saitama Medical Center Jichi Medical University
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Momomura Shin-ichi
Division Of Cardiovascular Medicine Department Of Integrated Medicine I Jichi Medical University Sai
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Ako Junya
Division Of Cardiovascular Medicine Department Of Integrated Medicine I Saitama Medical Center Jichi Medical University
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NISHIZAKI Mitsuhiro
Department of Cardiology, Yokohama Minami Kyosai Hospital
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Hojo Rintaro
Department of Cardiology, Tokyo Metropolitan Hiroo Hospital
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AKO Junya
Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University
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Hojo Rintaro
Department of Cardiology, Tokyo Metropolitan Hiroo General Hospital
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Hiraoka Masayasu
Japan Ministry of Health, Labor, and Welfare
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Sakurada Harumizu
Tokyo Metropolitan Health and Medical Treatment Corporation Ohkubo Hospital
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Ako Junya
Division of Cardiology, Department of Integrated Medicine I, Saitama Medical Center, Jichi Medical University School of Medicine
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Momomura Shin-ichi
Division of Cardiology, Department of Integrated Medicine I, Saitama Medical Center, Jichi Medical University School of Medicine
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