Elevated Levels of Brain Natriuretic Peptide in Patients Cured of Paroxysmal Atrial Fibrillation after Pulmonary Vein Isolation
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概要
- 論文の詳細を見る
<B>Background:</B> Little is known about long-term courses of brain natriuretic peptide (BNP) levels in patients with paroxysmal atrial fibrillation (PAF) who have a normal sinus rhythm after successful pulmonary vein isolation (PVI). <B>Objective:</B> The aim of this study was to investigate the changes in the BNP levels of patients who had successfully undergone PVI. <B>Methods and Results:</B> The study population included 56 consecutive patients (age, 63±12 years; men, 39) who had undergone PVI with no recurrence of arrhythmia in the follow-up periods of 1.9 years. Elevated BNP levels (i.e. ≥18.4 pg/mL) were observed in 39 (70%) patients at the baseline. Overall, the BNP levels had significantly decreased after successful ablation (from 62.9±81.4 pg/mL to 34.7±36.3 pg/mL, P<0.001). However, the BNP levels were reduced to within the normal range only in 10 out of the 39 (26%) patients with elevated BNP levels at the baseline. <B>Conclusion:</B> The BNP levels had decreased in patients cured of PAF after successful PVI. In spite of elimination of arrhythmia, most of the patients show a mild elevation in their BNP levels, which remained far below the cut-off value for heart failure (100 pg/mL).
著者
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Hiraoka Masayasu
Tokyo Medical and Dental Uni.
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Fukamizu Seiji
Department Of Cardiology Surugadai Nihon University Hospital
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Sakurada Harumizu
Department Of Cardiology Metropolitan Hiroo Hospital
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Soejima Kyoko
Department Of Cardiology Keio University Hospital
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Komiyama Kota
Department Of Allergy And Rheumatology Japanese Red Cross Medical Center Hospital
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Tejima Tamotsu
Department Of Cardiology Tokyo Metropolitan Hiroo General Hospital
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Nishizaki Mitsuhiro
Department Of Cardiology Yokohama Minami Kyosai Hospital
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Tanabe Yasuhiro
Department Of Cardiology Tokyo Metropolitan Hiroo General Hospital
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Hayashi Takekuni
Department Of Cardiology Saitama Medical Center Jichi Medical University
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Abe Tomomi
Department Of Cardiology Kitano Hospital Medical Research Institute
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Matsushita Noriko
Department Of Applied Chemistry. Faculty Of Engineering Toyama University
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Komiyama Kota
Department of Cardiology, Tokyo Metropolitan Hiroo General Hospital
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NISHIZAKI Mitsuhiro
Department of Cardiology, Yokohama Minami Kyosai Hospital
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Hojo Rintaro
Department of Cardiology, Tokyo Metropolitan Hiroo Hospital
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Hayashi Takekuni
Department of Cardiology, Tokyo Metropolitan Hiroo General Hospital
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Hojo Rintaro
Department of Cardiology, Tokyo Metropolitan Hiroo General Hospital
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Abe Tomomi
Department of Cardiology, Tokyo Metropolitan Hiroo General Hospital
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Matsushita Noriko
Department of Cardiology, Tokyo Metropolitan Hiroo General Hospital
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Tanabe Yasuhiro
Department of Cardiology, Tokyo Metropolitan Hiroo General Hospital
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