An Attempt to Correct Interlaboratory Differences on Serum Total Cholesterol Determinations

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The Central Committee of Preventive Medicine Project has been undertaking a nationwide health check-up study on cardiovascular diseases in children, in which the serum total cholesterol (TC) and other related analytes were measured. In these nationwide examinations, it is a prerequisite to ensure the accuracy of the measured values from different district branch laboratories and maintain the interchangeability of data from these laboratories to determine any differences in TC values in various districts. To improve the interchangeability of the measured values among the laboratories and correct interlaboratory differences, we analyzed the control survey results which had been carried out yearly from 1988 to 1992. Compared with the first survey, subsequent survey results showed gradual improvements each time in both inter- and intralaboratory variation, eventually reaching a CV of 2.2-2.6%. Frozen pooled sera and lyophilized sera were used for these surveys, but lyophilized samples were found unsuitable. It was important to use the survey samples the accuracy of which were assured by the use of certified reference materials or secondary reference materials as calibrators. These reference materials could contribute significantly to obtain a correction factor and to correct the measured values in each laboratory. So, these control survey samples with defined target values are valuable for improvement of the accuracy of measurement of TC concentration.
Japan Society of Clinical Chemistryの論文

An Attempt to Correct Interlaboratory Differences on Serum Total Cholesterol Determinations

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