A study of serum platelet-activating factor acetylhydrolase (PAF-AH) activity in type 2 diabetes mellitus patients with hyperlipidemia

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Serum PAF-AH (platelet-activating factor acetylhydrolase) is considered to play a defensive role in allergic, inflammatory, and atherosclerotic diseases.<BR>We investigated the clinical significance of the serum PAF-AH activity assay in patients with type 2 diabetes mellitus (DM).<BR>Reference interval in normal men (223-683 IU/L) was higher than in women (183-538 IU/L)(p<0.01). Both of the serum PAF-AH activities for all and men in DM were not significantly different from those reference intervals. On the other hand, the serum PAF-AH activities for women in DM was significantly higher than its reference interval. The serum PAF-AH activities of DM with hyperlipidemia and polydisperse low density lipoproteinemia were higher than that of normal subjects. Therefore, the PAF-AH activity assay seemed to be very useful for estimation of clinical prognosis in DM with hyperlipidemia and polydisperse low density lipoproteinemia.

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