The Formation of N-de-ethyl Derivatives of 4, 4' Bis (β-diethylaminoethoxy)-α, β -diethyldiphenylethane by Red Blood Cells

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We investigated the possibility that red blood cells dealkylate 4, 4' -bis(β -diethylamino-ethoxy) α, β-diethyldiphenylethane (DH), which caused a peculiar drug-induced lipidosis. It is suggested that this reaction involves hemoglobin since both the hemolysate, with or without ghosts and the crystalized hemoglobin caused dealkylation of DH. The dealkylation of DH in red blood cells was reduced by the replacement of oxygen with nitrogen and enhanced by NADPH. We investigated the interaction between DH and hemoglobin, since the absorption spectra of the hemolysate and crystalized hemoglobin in the presence of DH was similar to that of cytochrome P450. We speculate that red blood cells may have an important role in the extrahepatic metabolism of drugs.
Japan Society of Clinical Chemistryの論文