URIC ACID METABOLISM IN CANCER OF THE PROSTATE
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It has been noticed that serum uric acid levels are low in patients with cancer of the prostate. For the purpose of evaluation of this fact, comparative studies of serum uric acid levels were carried out between cancer of the prostate and prostatic hypertrophy. In addition to it, the changes of uric acid, creatinine, various proteins such as α<SUB>1</SUB>-Acid Glycoprotein (α<SUB>1</SUB>-AG), α<SUB>1</SUB>-Antitrypsin (α<SUB>1</SUB>-AT), Ceruloplasmin (Cp), Antithrombin III (AT-III), and α<SUB>2</SUB>-Macroglobulin (α<SUB>2</SUB>-M) in the serum following the administration of synthetic female hormone in the cases of cancer of the prostate were studied.<BR>The results were summarized in the following. (1) Significant decreases of serum uric acid and creatinine levels were confirmed in cancer of the prostate in comparison with those in prostatic hypertrophy. (2) Following the administration of "Diethylstilbestrol diphosphate (Honvan)", serum uric acid levels showed a tendency to decrease in cancer of the prostate. (3) Among the cancers of the urogenital tract, decreases of α<SUB>1</SUB>-AG and AT-III and an increase of Cp were significantly documented in cancer of the prostate.<BR>These findings suggest that there is the presence of the state of relative increase of "female hormone" in the cases of cancer of the prostate, and that this might be play in some role in the development of cancer in the prostate. It is also assumed that serum uric acid levels could be used as an useful parameter for the evaluation of the state of fgmale hormone in the serum.
- Japanese Society of Gout and Nucleic Acid Metabolismの論文
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- URIC ACID METABOLISM IN CANCER OF THE PROSTATE