Hypouricemia due to Renal Urate Wasting Two Types of Urate Transport Abnormality
スポンサーリンク
概要
- 論文の詳細を見る
We presented two patients associated with hypouricemia. Their serum uric acid levels were 1.6 and 1.3 mg/100ml, respectively. One patient,28 aged female, had a history of urolithiasis and showed microhematuria. Another,47 aged female, had mild hypertension and microhematuria. No other family members have been proven to have hypouricemia. These two patients gave markedly increased urate clearance and normal G F R. Other findings which indicate renal tubular dysfunction, such as glycosuria, amino aciduria, decreased phosphate reabsorption and renal tubular acidosis, were not demonstrated in them. Hypercalciuria was also not be detected.<BR>In pyrazinalnide (PZA) suppression test, these two showed different response of urate excretion. In one patient urate excretion was slightly suppressed following PZA administration. Following benzbromarone, which inhits urate reabsorption in the tubule, urate excretion almost unchanged. This patient is considered to have a defect of urate reabsorption in the proximal tubule, resulting renal urate wasting.<BR>Another patient, on the other hand, showed marked decrease of urate excretion following PZA. This result suggests that increased urate clearance in this patient is due to either enhanced secretion or diminished reabsorption of secreted urate in the tubule. Uricosuric response to benzbromarone was far lesser than in seven normal controls. Suppression rate of urate excretion following PZA under benzbromarone-induced uricosuria was similar to the value of normals. These results suggest that this patient has a defect of postsecretory reabsorption of urate in the tubule, but not enhanced secretion of urate.<BR>Renal uricosuria with hypouricemia is a rare disease and it is considered that there are some subtypes of urate transport defect which cuases renal urate wasting.
- Japanese Society of Gout and Nucleic Acid Metabolismの論文
著者
関連論文
- 18. 腎障害者における筋エネルギー代謝異常について(第2回日本体力医学会北陸地方会)
- Antistreptolysin-O (ASO)高値と腎動脈などの急速な血管病変の進展を示した大動脈炎症候群の1例
- 巨大血小板性血小板減少症・難聴・腎炎および白内障を合併した遺伝性疾患の1家系
- 高レニン血症を伴つた原発性副甲状腺機能亢進症(癌)の1剖検例
- 吸収障害を合併した滲出性胃腸症の1例
- Cushing症候群を合併した家族性甲状腺髄様癌の1例
- 電撃傷に伴う急性腎不全の救命例--血漿交換療法の新しい適応
- Temporal arteritisの1例
- A case of membranous nephropathy associated with renal hypouricemia
- タイトル無し
- Clinical evaluation of CG - 120 (Uralyt -U):The combined effect with uricosuric agent; Benzbromarone preparation
- Hypouricemia due to Renal Urate Wasting Two Types of Urate Transport Abnormality
- Uric acid metabolism in primary hyperparathyroidism
- Uric acid metabolism in patients with chronic renal failure under maintenance hemodialysis
- A case of acute hemolytic transfusion resction due to alloantibodies against diego b, kidd a and Rh-Hr (E, c), resulting in disseminated intravascular coagulation and renal failure.
- タイトル無し
- Derangment of Uric Acid Metabolism in Acute Leukemia
- A case of familial renal hypouricemia associated with acute renal failure