Changes of cerebral uric acid level in experimental cold injury of rat brain and contused brain of man

概要

論文の詳細を見る
Uric acid levels in contused cerebral tissue were measured by high-performance liquid chromatography with an electrochemical detector in 11 patients with severe closed head injury. The concentration of uric acid appeared to increased with the severity of the contusion.<BR>To clarify these findings, the following experiment was done. Cold injury was produced on right cerebral hemisphere in rats. Uric acid was measured in the injured and contralateral cerebral hemispheres from 1 hour to 1 week after injury. The cerebral uric acid level was significantly increased at 48 hours.<BR>We analyzed the changes of the cerebral uric acid level after administration of allopurinol, a specific inhibitor of xanthine oxidase, in rats with cold injury Allopurinol markedly suppressed the increase of uric acid 3 hours after injury.<BR>These results suggest that in injured brain tissue, uric acid is generated from xanthine or hypoxanthine by xanthine oxidase. Thus, the end-product of purine degradation in mammalian brain is considered to be uric acid.
Japanese Society of Gout and Nucleic Acid Metabolismの論文