Magnetic Resonance Elastography for Staging Liver Fibrosis in Chronic Hepatitis C
スポンサーリンク
概要
- 論文の詳細を見る
Purpose: We evaluated the use of magnetic resonance (MR) elastography (MRE) for staging liver fibrosis in patients with chronic hepatitis C and compared the ability of MRE and serum fibrosis markers for discriminating each stage of fibrosis. Methods: We evaluated 114 patients with chronic hepatitis C in whom the pathological fibrosis stage was determined (fibrosis stage 0 [F0], 3; F1, 15; F2, 28; F3, 25; and F4, 43). All patients underwent MRE using a 1.5-tesla MR system and pneumatic driver system. We measured stiffness values (kPa) of the liver in a circular region of interest placed on elastograms. We determined the optimal cutoff value and diagnostic ability for discriminating each stage of fibrosis using receiver operating characteristic (ROC) curve analysis and compared the discriminative ability of MRE with that of serum fibrosis markers. Results: The mean stiffness values of the liver increased with stage of fibrosis: F0, 2.10±0.10 kPa; F1, 2.42±0.29 kPa; F2, 3.16±0.32 kPa; F3, 4.21±0.78 kPa; and F4, 6.20±1.08 kPa. The mean area under the ROC curve (Az) values for discriminating liver fibrosis stages were: ≥F1, 0.984 (95% confidence interval, 0.933–0.996); ≥F2, 0.986 (0.956–0.996); ≥F3, 0.973 (0.935–0.989); and ≥F4, 0.976 (0.945–0.990). The Az values for discriminating fibrosis stages were significantly higher for MRE than serum fibrosis markers. Conclusion: MRE is a reliable technique for staging liver fibrosis and discriminating liver fibrosis stages in patients with chronic hepatitis C.
著者
-
MOTOSUGI Utaroh
Department of Pathology, Saitama International Medical Center, Saitama Medical University
-
Matsuda Masanori
First Department Of Internal Medicine Showa University
-
Enomoto Nobuyuki
First Department Of Internal Medicine Faculty Of Medicine University Of Yamanashi
-
Sano Katsuhiro
Department Of Neurological Surgery Niigata Rosai Hospital
-
Araki Tsutomu
Department Of Applied Physics Faculty Of Engineering Osaka University
-
Ichikawa Tomoaki
Department Of Radiology School Of Medicine Kyorin University
-
Fujii Hideki
First Department Of Surgery Department Of Medicine Yamanashi University
-
MORISAKA Hiroyuki
Department of Radiology, University of Yamanashi
-
ICHIKAWA Shintaro
Department of Radiology, University of Yamanashi
関連論文
- Down-regulation of members of glycolipid-enriched membrane raft gene family, MAL and BENE, in cervical squamous cell cancers
- Discrepant uptake between fluorine-18 fluorodeoxy glucose and Tc-99m sestamibi in bronchioloalveolar cell carcinoma
- Left Ventricular Systolic and Diastolic Function Measured by ECG-Gated Blood Pool Single-Photon Emission Tomography
- Association of Mast Cell Chymase Gene Variant with HDL Cholesterol, but not with Blood Pressure in the Ohasama Study
- Mutational Analysis of BRCA1 Gene in Ovarian and Breast-ovarian Cancer Families in Japan
- Hepatic Metastasis 12 Years after Nephrectomy for Renal Cell Carcinoma
- A/C^ Gene Polymorphism of the Angiotensin II Type 1 Receptor (AT1) and Ambulatory Blood Pressure : the Ohasama Study
- T+31C Polymorphism (M235T) of the Angiotensinogen Gene and Home Blood Pressure in the Japanese General Population : the Ohasama Study
- Genetic polymorphisms in the beta-subunit of the epithelial sodium channel (βENaC) gene in the Japanese population
- IS-79 The immunosuppressant drug FK506 ameliorates neonatal cerebral mitochondrial dysfunction and energy failure after transient intrauterine ischemia in rats
- Changes in Uterine and Ovarian Arterial Impedance during the Periovulatory Period in Conception and Nonconception Cycles
- Secondary Mitochondrial Dysfunction after Transient Intrauterine Ischemia in the Fetal Rat Brain
- Characteristics of gefitinib-acquired resistant non-small cell lung cancer cell lines
- 3D-CT Angiography of Cerebral Arteriovenous Malformations
- Recent advances in pancreaticobiliary maljunction
- Magnetic Resonance (MR) Differentiation of Hepatocellular Carcinoma from Hepatic Cavernous Hemangioma: Efficacy of T2 Values for Tumors Smaller than 2 cm
- Decreased Signal Intensity of Cerebral Cortex on T2 - Weighted MR Images
- Intraosseous Ganglion Communicating with Soft Tissue Counterpart
- Decreased CD3 ζ molecules of T lymphocytes from patients with hepatocellular carcinoma associated with hepatitis C virus
- Hepatic steatosis in chronic hepatitis C is a significant risk factor for developing hepatocellular carcinoma independent of age, sex, obesity, fibrosis stage and response to interferon therapy
- Three Aberrant Splicing Variants of the HMGIC Gene Transcribed in Uterine Leiomyomas
- Frequent Allelic Loss at 7p14-15 Associated with Aggressive Histologic Types of Breast Cancer
- Griseofulvin, an oral antifungal agent, suppresses hepatitis C virus replication in vitro
- Effects of ion channel modulators in the influx and efflux of Tc-99m-MIBI
- Scan findings of various myocardial SPECT agents in a case of amyloid polyneuropathy with suspected myocardial involvement
- Tc-99m-MIBI scintigraphy for detecting parathyroid adenoma and hyperplasia
- Tl-201 uptake and retention in a Warthin's tumor
- Application of Tc-99m-tetrofosmin as a tumor imaging agent: Comparison with Tl-201
- Uptake and washout of I-123-MIBG in neuronal and non-neuronal sites in rat hearts: Relationship to renal clearance
- Doppler Ultrasound Measurement of Cerebral Blood Flow in Healthy Pregnant Women
- The Effect of Maternal Exercise on Ventricular Output in the Human Fetus
- Changes in myocardial oxidative metabolism after biventricular pacing as evaluated by [^C]acetate positron emission tomography
- Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor 3
- Effect of H-7 on Cerebral Ischemia: Evaluated by Diffusion Weighted MR Imaging
- Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication
- Development of the prefrontal lobe in infants and children : a three-dimensional magnetic resonance volumetric study
- The Separation of Two Reduction Products of Nitroblue Tetrazolium (Nitro BT) in Paramecium caudatum Using a Microphotometric Image-Analysis System
- Complete remission of multiple recurrent hepatocellular carcinomas by oral administration of enteric-coated tegafur/uracil in a patient with huge hepatocellular carcinoma extending to the inferior vena cava after hepatic resection : analysis of mRNA expre
- Predictors of hepatic venous trunk invasion and prognostic factors in patients with hepatocellular carcinomas that had come into contact with the trunk of major hepatic veins
- Synchronously resected double primary hepatic cancers : hepatocellular carcinoma and cholangiolocellular carcinoma
- A Huge Primary Peritoneal Papillary Adenocarcinoma Which Demonstrated Imaging Findings Similar to Those of Extrahepatic-Growing Type Hepatic Tumor : Report of a Case
- Surgical treatment of recurrent hepatocellular carcinoma based on the mode of recurrence : repeat hepatic resection or ablation are good choices for patients with recurrent multicentric cancer
- A Microspectrophotometer for Spectral Image Analysis
- Stabilization of intracellular DNA assay with Hoechst 33258 fluorochrome (II)
- Studies on Heterogeneity of Fluorescence Labeled Chromatin
- Biparametric Microfluorometry of Chlorotetracycline to Cellular DNA and Dental Structure
- Microphotometric Assay of SH Content per Tissue Protein
- THE EFFECT OF PHYSICAL TRAINING ON THERMOREGULATORY RESPONSES OF PREADOLESCENT BOYS TO HEAT AND COLD
- AGE DIFFERENCES IN SWEATING DURING MUSCULAR EXERCISE
- Histopathological Analysis of Intrahepatic Multiple Hepatocellular Carcinomas - Possibility of Differential Didgnosis of Their Origins by Clonal Study
- Development of a Simple Chemiluminometer to Determine Acid Value of Edible Oil Free of the Inner-Filter Effect
- Relationship between maximum standardized uptake value (SUVmax) of lung cancer and lymph node metastasis on FDG-PET
- Sex difference in the expression and regulation of nitric oxide synthase gene in the rat preoptic area
- Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells
- IS-106 Questions of Oxygen Therapy
- MR-guided Intravascular Catheter Manipulation: Feasibility of Both Active and Passive Tracking in Experimental Study and Initial Clinical Applications
- Basal Metabolic Rate in Pregnant Women Complcated with Preeclampsia : Enhanced Early Detection of The Disease.(Session13 Perinatology3)
- Changes in Maternal Peripheral T Helper 1-Type and T Helper 2-Type Immunity during Labor
- Changes in Fetal Plasma Adenosine and Xanthine Concentrations during Fetal Asphyxia with Maternal Oxygen Administration in Ewes
- B-Cell-Type Malignant Lymphoma with Placental Involvement
- Comparison of True FISP with Turbo SE in Ovarian Imaging
- DICKKOPF-4 and -2 genes are upregulated in human colorectal cancer
- Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy
- Fusion of a Sequence from HEI10 (14q11) to the HMGIC Gene at 12ql5 in a Uterine Leiomyoma
- Effects of Traps Formed by Threading Dislocations on Off-State Breakdown Characteristics in GaN Buffer Layer in AlGaN/GaN Heterostructure Field-Effect Transistors
- Active MR Tracking on a 0.2 Tesla MR Imager
- Maturation- and Aging-related Changes in Heat Loss Effector Function
- Gene fusion involving HMGIC is a frequent aberration in uterine leiomyomas
- Vertebral Artery Dissecting Aneurysm Rebleeding After Proximal Occlusion : Case Report
- Bronchiolitis Obliterans Organizing Pneumonia after Tangential Beam Irradiation to the Breast : Discrimination from Radiation Pneumonitis
- Mutations in the interferon sensitivity determining region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection
- A Simple Photomultiplier Gating Circuit for the Nanosecond Region
- High Speed Spectroscopic Measurement of Very Weak Radiation with Multichannel Coincidence Technique : Very Weak Light
- A predictive model of response to peginterferon ribavirin in chronic hepatitis C using classification and regression tree analysis
- Growth of Hlgh-Electron-Mobility InN by RF Molecular Beam Epitaxy : Semiconductors
- Small invasive ductal adenocarcinoma of the pancreas associated with lymphoplasmacytic sclerosing pancreatitis
- Somatic Mutations of the PTEN/MMAC1 Gene in Fifteen Japanese Endometrial Cancers : Evidence for Inactivation of Both Alleles
- Application of Droplet Elimination Process by Radical-Beam Irradiation to InGaN Growth and Fabrication of InN/InGaN Periodic Structure
- Dipyridamole Thallium-201 Single-Photon Emission Computed Tomography for Prediction of Perioperative Cardiac Events in Patients With Arteriosclerosis Obliterans Undergoing Vascular Surgery
- Two single nucleotide polymorphisms of the hSNF5/INI1 gene
- Radiation-induced Diffuse Brain Injury in the Neonatal Rat Model : Radiation-induced Apoptosis of Oligodendrocytes
- Prolonged treatment with pegylated interferon α 2b plus ribavirin improves sustained virological response in chronic hepatitis C genotype 1 patients with late response in a clinical real-life setting in Japan
- Polarity Determination of InN by Atomic Hydrogen Irradiation
- ITPA gene variant protects against anemia induced by pegylated interferon-α and ribavirin therapy for Japanese patients with chronic hepatitis C
- q-space Imaging (QSI) of the Brain : Comparison of Displacement Parameters by QSI and DWI
- Ultrastructural Changes in the Rat Endometrium during the Normal Estrous Cycle : Interactions between Epithelial Cells, Stromal Cells, Macrophages and Eosinophils
- Intradiploic epidermoid cyst with focal internal enhancement
- Accurate Stabilization of a 3mW Single-Mode Output He-Ne Laser by Intermittent Frequency Offset Locking to an Iodine Stabilized He-Ne Laser
- Intermittent Frequency Offset Lock of a Symmetric Three-Mode Stabilized He-Ne Laser to an Iodine Stabilized He-Ne Laser
- An Intermittent Frequency Offset Lock of a Transverse Zeeman Laser to an Iodine Stabilized He-Ne Laser
- Optical Glucose Monitoring Based on Femtosecond Two-Color Pulse Interferometry
- Multiple-Scattering-Free Optical Glucose Monitoring Based on Femtosecond Pulse Interferometry
- Loss of Heterozygosity at the HP Locus on Chromosome 16 in Hepatocellular Carcinoma
- Viral factors influencing the response to the combination therapy of peginterferon plus ribavirin in chronic hepatitis C
- Genetic changes in the interferon sensitivity-determining region of hepatitis C virus (HCV) during the natural course of infection : an implication for the gene function in the role of chronic infection
- Magnetic Resonance Elastography for Staging Liver Fibrosis in Chronic Hepatitis C
- Diffusion-and T_2-weighted MR Imaging of the Liver : Effect of Intravenous Administration of Gadoxetic Acid Disodium
- MR-based Measurements of Portal Vein Flow and Liver Stiffness for Predicting Gastroesophageal Varices
- Cancer preventive effect of pegylatecl interferon α-2b plus ribavirin in a real-life clinical setting in Japan : PERFECT interim analysis
- Magnetic Resonance Elastography for Staging Liver Fibrosis in Chronic Hepatitis C