Assessment of <SUP>123</SUP>I-MIBG Scintigraphy as a Diagnostic Tool for Neurally Mediated Syncope
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概要
- 論文の詳細を見る
<B>Background:</B> Iodine 123-labeled metaiodobenzylguanidine (123I-MIBG) scintigraphy has been used to evaluate cardiac dysfunction with sympathetic nerve disturbance. In this study, we assessed whether 123I-MIBG is useful as a tool for diagnosing neurally mediated syncope (NMS). <B>Methods:</B> We first performed head-up tilt (HUT) testing with impedance cardiogram monitor (Task Force® Monitor, CN Systems) in 26 patients (median age 57±17 years, 18 men) with unknown syncope in order to examine NMS. According to a result, patients were divided into the NMS and the non-NMS groups. We then performed 123I-MIBG scintigraphy and compared two parameters, i.e., the delayed heart/mediastinum (H/M) ratio and washout rate (WR) between both groups. <B>Results:</B> Seven patients were diagnosed syncope as NMS (mixed type in all) and the remaining 19 patients as non-NMS. As regards 123I-MIBG, delayed H/M ratio and WR were 2.4±0.2 and 26.2±10.1%, respectively in the NMS group, and 2.1±0.4 and 37.9±17.6%, respectively in the non-NMS group. Both delayed H/M ratio and WR did not differ between both groups (P=0.08 and P=0.11, respectively). <B>Conclusion:</B> No correlation exists between HUT testing and 123I-MIBG scintigraphy in patients with unknown syncope. 123I-MIBG scintigraphy is not useful as a diagnostictool for NMS and may be not associated with autonomic response with postural change.
- 日本不整脈学会の論文
著者
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Ikeda Takanori
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Fujino Tadashi
Department Of Cardiovascular Medicine Toho University Omori Medical Center
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Yuzawa Hitomi
Department Of Cardiovascular Medicine Toho University Omori Medical Center
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Fukunaga Shunji
Department of Cardiology, Kawasaki social insuarance hospital
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Sato Hideyuki
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Okano Yoshifumi
Department Of Cardiology Toho University Omori Medical Center
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Yamazaki Jyunichi
Department of Cardiovascular Medicine, Toho University Medical Center
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Kobayashi Kenzaburo
Department of Cardiovascular Medicine, Toho University Medical Center
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Kobayashi Kenzaburo
Department of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, Japan
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