Effects of Landiolol, an Ultra-Short-Acting β_1-Selective Blocker, on Electrical Storm Refractory to Class III Antiarrhythmic Drugs
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概要
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Background: Occasionally it is difficult to inhibit electrical storm (ES) with standard pharmacological treatment. In the present study the effect of landiolol, an ultra-short-acting β1-selective blocker, on ES refractory to class III antiarrhythmic drugs was evaluated. Methods and Results: The study group comprised 42 consecutive patients who developed ES for which intravenous class III antiarrhythmic drugs, such as amiodarone and nifekalant, were ineffective. Landiolol was administered intravenously with an initial dose of 2.5 μg · kg–1 · min–1, which was doubled if it was ineffective, up to a maximum dose of 80 μg · kg–1 · min–1. Landiolol inhibited ES in 33 patients (79%) at a mean dose of 7.5±12.2 μg · kg–1 · min–1. All patients in whom landiolol was ineffective died of arrhythmia. Of the 33 patients in whom landiolol was effective, 25 survived and were discharged (60% of all patients). Landiolol significantly decreased heart rate (P<0.0001), but did not affect blood pressure. Landiolol was not discontinued for adverse effects in any of the responders. Age, APACHE II score, and pH of arterial blood gas differed significantly between the responders and nonresponders. Conclusions: Landiolol is useful as a life-saving drug for class III antiarrhythmic drug-resistant ES. The main mechanism of ES refractory to class III antiarrhythmic drugs could be abnormal automaticity but not reentry.
- 社団法人 日本循環器学会の論文
- 2010-04-25
著者
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Ikeda Takanori
Kyorin University Hospital
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Yoshino Hideaki
Kyorin University Hospital
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Hiasa Yoshikazu
on behalf of j-Cypher Registry Investigators
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Ikeda Takanori
The Second Department Of Internal Medicine Kyorin University School Of Medicine
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Ikeda Takanori
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Yoshino Hideaki
Second Department Of Internal Medicine Kyorin University School Of Medicine
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Yoshino Hideaki
Department Of Cardiology Kyorin University School Of Medicine
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Ishiguro Haruhisa
Second Department of Internal Medicine, Kyorin University School of Medicine
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Ikeda Takanori
Second Department of Internal Medicine, Kyorin University School of Medicine
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Abe Atsuko
Second Department of Internal Medicine, Kyorin University School of Medicine
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Tsukada Takehiro
Second Department of Internal Medicine, Kyorin University School of Medicine
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Mera Hisaaki
Second Department of Internal Medicine, Kyorin University School of Medicine
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Yusu Satoru
Second Department of Internal Medicine, Kyorin University School of Medicine
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Mera Hisaaki
Second Department Of Internal Medicine Kyorin University School Of Medicine
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Ishiguro Haruhisa
Second Department Of Internal Medicine Kyorin University School Of Medicine
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Yusu Satoru
Second Department Of Internal Medicine Kyorin University School Of Medicine
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Tsukada Takehiro
Second Department Of Internal Medicine Kyorin University School Of Medicine
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Yoshino Hideaki
Department Of Cardiovascular Medicine Kyoto University
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Miwa Yosuke
Second Department of Internal Medicine, Kyorin University School of Medicine
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Miyakoshi Mutsumi
Second Department of Internal Medicine, Kyorin University School of Medicine
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Miwa Yosuke
Second Department Of Internal Medicine Kyorin University School Of Medicine
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Miyakoshi Mutsumi
Second Department Of Internal Medicine Kyorin University School Of Medicine
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HOSHIDA Kyoko
Second Department of Internal Medicine, Kyorin University School of Medicine
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YANAGISAWA Ryoji
Second Department of Internal Medicine, Kyorin University School of Medicine
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Hoshida Kyoko
Second Department Of Internal Medicine Kyorin University School Of Medicine
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Abe Atsuko
Second Department Of Internal Medicine Kyorin University School Of Medicine
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Ikeda Takanori
Second Department Of Internal Medicine Kyorin University
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Yoshino Hideaki
Second Department Of Internal Medicine Kyorin University
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Yoshino Hideaki
Cardiology Kitasato University School Of Medicine
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Yoshino Hideaki
The Second Department Of Internal Medicine Kyorin University School Of Medicine
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Ikeda Takanori
Department Of Cardiovascular Medicine Kyoto University
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Yanagisawa Ryoji
Second Department Of Internal Medicine Kyorin University School Of Medicine
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Yoshino Hideaki
Second Department Of Internal Medicine Cardiology Kyorin University School Of Medicine
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Yoshino Hideaki
Department Of Cardiology Kyorin University Faculty Of Medicine
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