ペルヒドロポリシラザンから作製したＳｉＯ２膜の構造分析と生体活性能の評価

概要

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Bioactive ceramics, one of the most popular biomaterial, is now widely used for bone-repairing. However, its application is limited to less loaded regions because of its low fracture toughness. We focused on Perhydropolysilazane (PHPS) which is an organosilicate polymer consisting of cyclic (SiH2-NH)n units. PHPS converts easily to silicon dioxide by heat-treatment lower than 150°C and is capable of compounding with low-melting polymers. By compounding with such materials SiO2 film bearing several mechanical properties can be cured from PHPS. In this study, SiO2 films were cured under various conditions. In order to investigate the existence of Si-OH, inducing the nucleus formation of apatite, sample surfaces were characterized by Fourier transform infrared reflection (FT-IR). Bioactiveness of each samples was tested by immersing in Simulated body fluid (SBF), solution which ion concentration is nearly equal to that of human blood plasma, for seven days. From the immersion tests, some samples showed bioactivity. Zeta potential of each samples were also measured. The dissolution of SiO2 films under immersion were examined by Atomic absorption spectroscopy (AAS). From these results, SiO2 films of (i) relatively less Si-H, witch repels the Ca ion bonding, (ii) surface Si-OH existing without condensation, (iii) Si-O-2NBO (Non-bridging oxygen) containing siloxane structure witch encourages the dissolution of silicate ion, showed bioactivity.