A History of Ischemic Heart Disease is a Common Cause of Wheezing in the Elderly of a Japanese Local Community
スポンサーリンク
概要
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Objective We conducted a cross-sectional study to investigate which factors have a significant impact on wheezing and QOL in the elderly of a Japanese local community. Methods In 2008, 527 participants (250 participants aged 45 to 64 years and 277 participants aged 65 to 88 years) responded to the questionnaire regarding wheezing and disease history. QOL was evaluated by the Short Form-8. The participants underwent airway reversibility testing. The plasma levels of IgE were measured. The plasma levels of N-terminal-pro-B-type natriuretic peptide were measured in twenty-one participants with a history of ischemic heart disease and in thirty-five age-matched participants without that history. Results Wheezing was reported by 50 (9.5%) participants and was associated with a lower score of QOL. In multivariate analysis, wheezing was associated with sex (OR 3.12, CI 1.10-9.67) and a history of bronchial asthma (OR 22.3, CI 6.50-84.0) among participants aged 45 to 64 years. Among participants aged 65 and over, wheezing was associated with a history of bronchial asthma (OR 4.86, CI 1.39-15.1) and ischemic heart disease (OR 5.12, CI 1.61-15.0). Participants with both a history of ischemic heart disease and wheezing showed higher levels of N-terminal-pro-B-type natriuretic peptide. Airway reversibility was only associated with a history of ischemic heart disease (OR 4.65, CI 1.26-17.6). Conclusion It is suggested that bronchial asthma and heart disease are both significant causes of wheezing and affect the QOL in the elderly of a Japanese local community.
著者
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Origasa Hideki
Division Of Biostatistics And Clinical Epidemiology University Of Toyama Graduate School Of Medicine
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MATSUI Shoko
Health Administration Center, Sugitani Campus, University of Toyama
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Tobe Kazuyuki
The First Department of Internal Medicine, School of Medicine, University of Toyama, Toyama 930-0194, Japan
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Matsui Shoko
Health Administration Center, University of Toyama, Japan
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Iwata Minoru
The First Department of Internal Medicine, Faculty of Medicine, University of Toyama, Japan
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Taka Chihiro
The First Department of Internal Medicine, Faculty of Medicine, University of Toyama, Japan
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Inomata Minehiko
The First Department of Internal Medicine, University of Toyama, Japan
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Kawagishi Yukio
The First Department of Internal Medicine, University of Toyama, Japan
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Tokui Kotaro
The First Department of Internal Medicine, University of Toyama, Japan
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Masaki Yasuaki
The First Department of Internal Medicine, University of Toyama, Japan
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Kambara Kenta
The First Department of Internal Medicine, University of Toyama, Japan
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Okazawa Seisuke
The First Department of Internal Medicine, University of Toyama, Japan
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Imanishi Shingo
The First Department of Internal Medicine, University of Toyama, Japan
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Ichikawa Tomomi
The First Department of Internal Medicine, University of Toyama, Japan
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Suzuki Kensuke
The First Department of Internal Medicine, University of Toyama, Japan
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Yamada Toru
The First Department of Internal Medicine, University of Toyama, Japan
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Usui Isao
The First Department of Internal Medicine, University of Toyama, Japan
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Sumi Shigeki
Center for the Advancement of Medical Training, University Hospital of Toyama, Japan
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Hayashi Ryuji
The First Department of Internal Medicine, University of Toyama, Japan
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Tobe Kazuyuki
The First Department of Internal Medicine, Faculty of Medicine, University of Toyama, Japan
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Tobe Kazuyuki
The First Department of Internal Medicine, University of Toyama, Japan
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Origasa Hideki
Division of Biostatistics and Clinical Epidemiology, University of Toyama, Japan
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