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Buprenorphine hydrochloride was intramuscularly injected at the usual dose into patients who required frequent use of analgesics, and its analgesic effect and drug dependence potential were studied during the course of treatment and after termination of treatment. 1. A total of 18 patients were studied: 11 patients with cancer-related pain, 3 patients with postoperative pain, 2 patients with postoperative ileus, and 2 patients with other symptoms. 2. The overall improvement in terms of analgesic efficiency was remarkable in 66.7% of the patients studied and moderate in 27.8%, so that the efficacy of the drug was very high. 3. The only side effects observed were slight dizziness in 1 patient and moderate decrease of respiration rate in another. 4. The drug dependence potential was examined in 14 patients who received more than 4 injections of buprenorphine hydrochloride. During the course of treatment, 10 patients (71.4%) requested continuation of the drug and 2 (14.3%) requested an increased dose. After termination of treatment, 2 patients (14.3%) requested resumption of the drug, 2 (14.3%) complained of sleeplessness and 1 (7.1%) complained of nervousness, but these were due to pain. During the course of treatment, 3 patients (21.4%) experienced an exhilarated feeling, but the symptom was mild, and hence, it was not considered to suggest dependency on the drug. 5. Although the number of patients was not large, the dependence potential of buprenorphine hydrochloride was studied in as much detail as possible. However, the results of the present study did not indicate any clinical problems with drug dependence potential.
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