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Fenbufen, 4-(4-biphenylyl)-4-oxobutyric acid, was compared with diclofenac in a double blind clinical trial of 107 randomly assigned patients with osteoarthritis of the knee joint. The trial was designed to determine the comparative efficacy and safety of the two drugs.<BR>The patients studied were treated with either fenbufen in the dosage of 600mg/day or diclofenac of 75mg/day alone for the period of 6 weeks.<BR>According to evaluation by physicians, the effectiveness was observed 83.3% in fenbufen and 75.0% in diclofenac groups. Of the eleven symptoms of osteoarthritis were selected for the study, fenbufen group demonstrated three statistically better symptoms than diclofenac group, i. e. pain in extension, pain at climbing up and down stairs (p<0.05).<BR>The incidence of drug related side effects was noted 10.5% in fenbufen group and, 25.0% in diclofenac group with statistically significant difference (p<0.05).<BR>Following to overall assessment which considers both efficacy and side effects, it might be concluded that fenbufen is significantly beneficial to patients than diclofenac.
一般社団法人日本臨床薬理学会の論文