全身麻酔におけるファモチジン前投与の有用性-筋肉内投与と静脈内投与の臨床的同等性の検討-

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Famotidine is a histamine H<SUB>2</SUB>-receptor antagonist that reduces gastric acid secretion. The effects of famotidine on gastric secretion were studied in 150 adult patients undergoing elective surgery. About one hour before induction of general anesthesia, 20 mg of famotidine was given to each patient either intramuscularly or intravenously at random. The volume and pH of gastric fluid aspirated via a gastric tube were measured immediately after orotracheal intubation and before extubation. In 67 of 76 patients (88.2%) given famotidine intramuscularly and 63 of 74 patients (85.1%) given famotidine intravenously, the gastric content pH was elevated above 2.5 or no gastric fluid could obtained any time during anesthesia. There were no significant side effects in either group.We conclude that intramuscular and intravenous famotidine are both useful preoperative medications to prevent aspiration pneumonia during general anesthesia.
一般社団法人日本臨床薬理学会の論文