Analysis of an 8-years interval of the Japanese Ministry of Health and Welfare's "Adverse Drug Reaction Monitoring" database.

概要

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1. Using information from the Ministry of Health and Welfare's "Adverse Drug Reaction (ADR) Monitoring System, " we previously compiled an 8-year database of 12, 241 adverse reactions that were reported between April 1980 and March 1988. We have analyzed these data.<BR>2. The most frequently reported drugs were co-trimoxazole (206 adverse reactions), amoxicillin (185), cephalexin (182), mefenamic acid (170), and indomethacin (156).<BR>3. The most frequently reported ADRs were dermatologic (4, 211), whole body (1, 517), digestive (1, 423), cardiovascular (1, 004), and hemic and lymphatic (993) disorders. The most -frequently reported drugs were classified as antibiotic (2, 863), central nervous system (including NSAIDs) (2, 793), dermatologic (1, 116), and cardiac (1, 033) drugs.<BR>4. Deaths (246) were associated mainly with antibiotics (89), central nervous system drugs (66), and diagnostic drugs (17).<BR>5. Associations between drugs and adverse effects were analyzed in the database. But the patient's age, sex, drug dose, concomitantdrugs, the duration of therapy, and the outcome of ADRs are not available in this "Adverse Drug Reaction Monitoring System." These items must be available for each reaction to make this monitoring system more useful.
一般社団法人日本臨床薬理学会の論文