EXPERIMENTAL AND CLINICAL STUDIES ON THE EFFECT OF PYRODIFENIUM BROMIDE (PADRIN) ON THE GASTROINTESTINAL TRACT
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Electromyographic studies on the effect of Pyrodifenium bromide (Padrin) on the motor function of the gastrointestinal tract of the dogs and human beings were carried out.<BR>1) Electromyographically, padrin when administered intravenously in an amount of 0.5mg. per kg. of body weight had a suppressing effect on the motility of the stomach of dogs. The drug also had a marked suppressing effect on the motility of the small intestine with the amount of 0.25mg. per kg. of body weight.<BR>2) The effect lasted from 30 to 45 min. in the small intestine and less than that in the stomach.<BR>3) Anti-peristalsis of the stomach was restored to normo-peristalsis by Padrin.<BR>4) The drug was effective in reducing the pain and other symptoms in 23 cases including patients of gastrointestinal disorders pre- and postoperatively.<BR>5) Two of the 23 cases developed dryness of the mouth that was only minor side effect noted.<BR>6) From the above-mentioned results, this drug proved to be useful clinically with its suppressing effect on the motor function of the gastrointestinal tract.
- 日本平滑筋学会の論文
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