Significance of Circulatory Disturbance in the Production of Experimental Gastric Ulcer

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概要

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• Etiology of gastric ulcer has remained as a subject of further investigation and few papers so far reported dealt with the systematic study concerning the etiologic factor of local circulatory disturbance. In this study, an experimental production of gastric ulcers was attempted by ligating gastric vessels accompanied with or without histamine injections.A total of 62 adult mongrel dogs were divided into five groups and after each preparation specific to the group, macroscopic findings of the gastric mucosa, microscopic findings, incidence of ulcer production and gastric acidity were observed. Duration of observations ranged from one to four weeks. Group I dogs were given a daily histamine injection only. In Group II dogs, all the gastric and gastroepiploic arteries were ligated. Group III dogs were subjected to the same preparation as in Group II followed by a daily histamine injection. Group IV dogs were subjected to the ligation of all the gastric as well as gastroepiploic vessels. In Group V dogs, daily histamine injection was given following the same preparation as done in Group IV. Single injection of histamine contained 50mg of histamine dichlotride mixed in beeswax and the injection was continued daily until the date of sacrifice.The results obtained are summarized as follows:1) Microscopic findings of ulcers: Experimental gastric ulcers produced either by histamine injection or by ligation of vessels, or combination of both were well similar to those seen in human. However, proliferation of the connective tissue at and adjacent to the ulcer base was absent and yet most of them were shallow ulcers.2) Incidence of gastric ulcer: Incidences of gastric ulcer production were 15.4% in Group I, 50% in Group II, 0% in Group III, 30.8% in Group IV and 100% in Group V.3) Gastric acidity in relation to ligation of vessels: Gastric acidity in group IV was much lower than the one in Group I which was not subjected to the ligation of gastric vessels.These results obtained in the present experiment suggest the importance of decrease in mucosal resistance as an etiologic factor of gastric ulcer rather than a factor of gastric acidity.

• 財団法人 日本消化器病学会の論文

著者

• 斎藤 禎量

  東北大学医学部第1外科学教室

• 斎藤 禎量

  東北大学医学部槇外科教室

関連論文

• Significance of Circulatory Disturbance in the Production of Experimental Gastric Ulcer
• EXPERIMENTAL AND CLINICAL STUDIES ON THE EFFECT OF PYRODIFENIUM BROMIDE (PADRIN) ON THE GASTROINTESTINAL TRACT

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