EFFECT OF VAGOTOMY ON THE ANTRAL MOTOR FUNCTION

概要

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In canine stomach, a mucosal septum was made at the boundary between the corpus and antrum with a balloon placed inside of the antral portion. By inflating the air, intraballoon pressure was raised to 30 and 40 cmH2O and the changes in antral motor function was studied before and after vagotomy with the use of electromyography. The results are summarized as follows. 1. Reaction to antral distension stimuli was compared before and after vagotomy.Findings after vagotomy were, in general, prolongation of discharge intervals, acceleration of propagation velocity and increased incidence of antiperistalsis with these indicating the less sensitivity to the stimuli of pressure increase. 2. Relationship between the intra-balloon pressure and the amount of air needed to inflate the balloon was as follows. After vagotomy, an increased amount of air was needed to obtain the same intra-balloon pressure suggesting the reduction in tonus of the gastric wall. The present study has revealed that the vagotomy reduces the motor function of the antral portion, tonus of the gastric wall and responses to the antral distension stimuli. Based on these findings, it is postulated that the vagotomy inhibits motor function of the antral portion.
日本平滑筋学会の論文