Asymmetric reduction of aromatic ketones with reagents prepared from NaBH4 and ZnCl2 in the presence of 1,2:5,6-di-O-isopropylidene-.ALPHA.-D-glucofuranose.
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概要
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Asymmetric reduction of prochiral aromatic ketones using a freshly prepared complex derived from NaBH<SUB>4</SUB>, 1/3 equiv of ZnCl<SUB>2</SUB>, and 1,2 : 5,6-di-<I>O</I>-isopropylidene-α-D-glucofuranose (<B>1</B>) gives an excess of the corresponding (<I>S</I>)-alcohols in substantial optical yields (28–68%). The effects of the NaBH<SUB>4</SUB>/ZnCl<SUB>2</SUB>/<B>1</B> ratio, temperature, solvent, structure of various monosaccharide derivatives, and the metal cation of the reagent on the optical yields were examined.
- 公益社団法人 日本化学会の論文
著者
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Hirao Akira
Department Of Agronomy Faculty Of Agriculture Tottori University
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MOCHIZUKI Hidenori
Department of Polymer Science, Tokyo Institute of Technology
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OHWA Masaki
Department of Polymer Science, Tokyo Institute of Technology
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Yamazaki Noboru
Department Of Biomaterials And Devices Kanagawa Dental College
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ITSUNO Shinichi
Department of Environmental and Life Sciences, Toyohashi University of Technology
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Nakahara Seiichi
Department of Polymer Science, Tokyo Institute of Technology
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Hirao Akira
Department of Polymer Science, Tokyo Institute of Technology
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