Asymmetric reduction of aromatic ketone in a continuous flow system.
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概要
- 論文の詳細を見る
When THF–borane (1/1) and aromatic ketone were supplied continuously to the column containing polymer-supported (<I>S</I>)-(−)-2-amino-3-(<I>p</I>-hydroxyphenyl)-1,1-diphenyl-1-propanol, the chiral product, secondary benzylic alcohol, could be obtained successfully (>90% ee). Large quantities of highly optically pure alcohol could be produced by the continuous flow system by the use of only a small amount of polymeric auxiliary.
- 公益社団法人 日本化学会の論文
著者
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Hirao Akira
Department Of Agronomy Faculty Of Agriculture Tottori University
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Maruyama Toshihiro
Department Of Medicine Kitakyushu Municipal Medical Center
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Nakahama Seiichi
Department Of Organic And Polymeric Materials Graduate School Of Science And Engineering Tokyo Insti
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Ito Koichi
School of Materials Science, Toyohashi University of Technology
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Itsuno Shinichi
School of Materials Science, Toyohashi University of Technology
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Kanda Naoki
Department of Polymer Science, Tokyo Institute of Technology
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Maruyama Toshihiro
Department of Polymer Science, Tokyo Institute of Technology
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