Mechanochemical change in the solid state of hexobarbital.
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概要
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The effect of ball-milling on X-ray diffraction diagrams, IR spectra, DTA and DSC thermograms of hexobarbital was investigated. It was found that the regularity at the crystal part changed upon ball-milling without any diluent. In addition to this change, an amorphous part increased upon ball-milling with microcrystal-line cellulose (MCC). The solubility in a KH<SUB>2</SUB>PO<SUB>4</SUB>–Na<SUB>2</SUB>HPO<SUB>4</SUB> buffer solution (pH 6.0) also increased upon ball-milling with MCC, though the solubility did not change without MCC. The analysis of IR spectra indicated that hydrogen bonds were formed between the C=O group of hexobarbital and the OH group of MCC upon ball-milling. Both the increase in the amorphous part and solubilization of hexobarbital upon ball-milling were attributed to the stabilization of the amorphous state caused by the interaction with MCC.
- 公益社団法人 日本化学会の論文
著者
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Hayakawa Sohachiro
Department Of Applied Physics Faculty Of Science Tokyo Institute Of Technology
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Ikekawa Akiko
Faculty of Pharmaceutical Sciences, Showa University
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