Optical resolution of DL-valine, DL-leucine, and DL-isoleucine by formation of adduct with L-phenylalanine.
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概要
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An alkaline solution containing L-phenylalanine (L-Phe) and one of DL-valine, DL-leucine, and DL-isoleucine is allowed to selectively form a precipitate composed of L-Phe and the aliphatic D-amino acid by adjusting the pH of initial solution to around 5.5 with hydrochloric acid. <SUP>1</SUP>H NMR spectra in deuterium oxide, elemental analyses, and infrared spectra of the precipitates indicate that they are adducts of the aliphatic D-amino acid and L-Phe in the molar ratio of 1:1. The free aliphatic DL-amino acids with high optical purity (84–100%) may be recovered from the adducts in 49–63% yield. An attempt was made to obtain both the aliphatic D- and DL-amino acids by using an aqueous solution containig the aliphatic DL-amino acid and L-Phe as an initial solution. The aliphatic L-amino acids obtained had optical purity of 47–85%.
- 公益社団法人 日本化学会の論文
著者
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KUROKAWA Hidemoto
Faculty of Engineering and High Technology Research Center, Kansai University
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Shiraiwa Tadashi
Faculty Of Chemistry Materials And Bioengineering Kansai University
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Sakaguchi Keiji
Faculty of Engineering, Kansai University
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Ikawa Akihiko
Faculty of Engineering, Kansai University
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