Asymmetric Transformations of Proline and 2-Piperidinecarboxylic acid via Formation of Salts with Optically Active Tartaric Acid.
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概要
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The rates of racemization of optically active proline [Pro] and 2-piperidinecarboxylic acid [Pia] by using aldehydes as a catalyst tended to increase with a decrease in the acidity of the carboxylic acid used as solvent. Based on these results, the asymmetric transformations of DL-Pro and (<I>RS</I>)-Pia were carried out via formation of salts with (2<I>R</I>, 3<I>R</I>)-tartaric acid to give optically pure L-Pro in over 80% yield and (<I>R</I>)-Pia in 70% yield. The asymmetric transformation of L-Pro was more successfully achieved by using (2<I>S</I>, 3<I>S</I>)-tartaric acid to give optically pure D-Pro in 85% yield based on the starting L-Pro.
- 公益社団法人 日本化学会の論文
著者
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KUROKAWA Hidemoto
Faculty of Engineering and High Technology Research Center, Kansai University
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Shiraiwa Tadashi
Faculty Of Chemistry Materials And Bioengineering Kansai University
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Shinjo Kazuyuki
Faculty of Engineering, Kansai University
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